Sequence polymorphisms of MC1R gene and their association with depression and antidepressant response

Gui Sheng Wu, Huai Rong Luo, Chuanhui Dong, Claudio Mastronardi, Julio Licinio, Ma Li Wong

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Objective: Melanocortin 1 receptor (MC1R) is involved in various functions, such as pigmentation, antipyretic and anti-inflammatory actions, development of melanoma, susceptibility to ultraviolet-induced sun damage, modification of oculocutaneous albinism, development of freckles, and mediation of female-specific mechanisms of analgesia. MC1R's natural agonists include α-melanocyte-stimulating hormone and corticotrophin (ACTH1-39), which are important components of hypothalamic pituitary adrenal axis and increase in response to stress. Given the multiple relevant roles of MC1R, we studied whether the MC1R gene would be associated with susceptibility to major depressive disorder or with response to antidepressant treatment. Methods: The human MC1R gene is highly polymorphic; therefore, we sequenced the entire MC1R coding region of 1122 bp in 181 depressed Mexican-American patients and 185 Mexican-American controls. Results: A total of 23 single nucleotide polymorphisms (SNPs, 15 known and eight new) were found within the sequenced region. Among the common SNPs, the nonsynonymous SNP, rs885479 (R163Q) was associated with the diagnosis of depression (P=0.04). The nonsynonymous SNP, rs2228479 (V92M) and the synonymous SNP, rs2228478 were found to be associated with the remission with desipramine treatment. No associations were found for remission with fluoxetine treatment or for the combined sample treated with fluoxetine or desipramine. The frequency of one (H2) of the five haplotypes identified was higher in depressed patients when compared with controls (P=0.05). In-silico functional analysis indicates that SNPs rs885479 and rs2228479 have significant impact on the protein function. Conclusion: The MC1R gene might be associated with major depressive disorder and with treatment response to desipramine.

Original languageEnglish
Pages (from-to)14-18
Number of pages5
JournalPsychiatric Genetics
Volume21
Issue number1
DOIs
StatePublished - Feb 1 2011

Fingerprint

Receptor, Melanocortin, Type 1
Antidepressive Agents
Single Nucleotide Polymorphism
Depression
Desipramine
Genes
Fluoxetine
Major Depressive Disorder
Oculocutaneous Albinism
Melanocyte-Stimulating Hormones
Melanosis
Antipyretics
Pigmentation
Solar System
Therapeutics
Computer Simulation
Adrenocorticotropic Hormone
Analgesia
Haplotypes
Melanoma

Keywords

  • antidepressant
  • association
  • haplotype
  • major depression
  • melanocortin 1 receptor
  • single nucleotide polymorphisms

ASJC Scopus subject areas

  • Genetics(clinical)
  • Psychiatry and Mental health
  • Genetics
  • Biological Psychiatry

Cite this

Sequence polymorphisms of MC1R gene and their association with depression and antidepressant response. / Wu, Gui Sheng; Luo, Huai Rong; Dong, Chuanhui; Mastronardi, Claudio; Licinio, Julio; Wong, Ma Li.

In: Psychiatric Genetics, Vol. 21, No. 1, 01.02.2011, p. 14-18.

Research output: Contribution to journalArticle

Wu, Gui Sheng ; Luo, Huai Rong ; Dong, Chuanhui ; Mastronardi, Claudio ; Licinio, Julio ; Wong, Ma Li. / Sequence polymorphisms of MC1R gene and their association with depression and antidepressant response. In: Psychiatric Genetics. 2011 ; Vol. 21, No. 1. pp. 14-18.
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AU - Wu, Gui Sheng

AU - Luo, Huai Rong

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AU - Licinio, Julio

AU - Wong, Ma Li

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