Sequence and evolution of cattle MHC class I cDNAs: concerted evolution has not taken place in cattle

Theodore L. Garber, Austin L. Hughes, Norman L. Letvin, Joe W. Templeton, David Watkins

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

To explore genetic mechanisms responsible for major histocompatibility complex (MHC) class I evolution in the artiodactyls, we cloned and sequenced MHC class I cDNAs from a Bos taurus bull heterozygous for cattle MHC (BoLA) class I serological specificities w2 and w30. Four unique cDNAs were found, indicating the presence of at least two MHC class I loci. Analysis of these four cDNAs and all previously published BoLA cDNA sequences suggested that there may be three cattle MHC class I loci. Additionally, comparison of all of the BoLA class I cDNAs to MHC class I cDNAs of other artiodactyls showed that some of the BoLA class I cDNAs were more similar to certain sheep cDNAs than they were to other cattle cDNAs. These data indicate that each BoLA class I locus has evolved independently after an ancestral gene duplication event and that inter-locus segmental exchange o or concerted evolution has not occurred rapidly enough to cause extensive divergence between the orthologous MHC class I loci of sheep and cattle.

Original languageEnglish
Pages (from-to)11-20
Number of pages10
JournalImmunogenetics
Volume38
Issue number1
DOIs
StatePublished - Mar 1 1993
Externally publishedYes

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Major Histocompatibility Complex
Complementary DNA
Sheep
Gene Duplication

ASJC Scopus subject areas

  • Immunology
  • Genetics

Cite this

Sequence and evolution of cattle MHC class I cDNAs : concerted evolution has not taken place in cattle. / Garber, Theodore L.; Hughes, Austin L.; Letvin, Norman L.; Templeton, Joe W.; Watkins, David.

In: Immunogenetics, Vol. 38, No. 1, 01.03.1993, p. 11-20.

Research output: Contribution to journalArticle

Garber, Theodore L. ; Hughes, Austin L. ; Letvin, Norman L. ; Templeton, Joe W. ; Watkins, David. / Sequence and evolution of cattle MHC class I cDNAs : concerted evolution has not taken place in cattle. In: Immunogenetics. 1993 ; Vol. 38, No. 1. pp. 11-20.
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