Abstract
To explore genetic mechanisms responsible for major histocompatibility complex (MHC) class I evolution in the artiodactyls, we cloned and sequenced MHC class I cDNAs from a Bos taurus bull heterozygous for cattle MHC (BoLA) class I serological specificities w2 and w30. Four unique cDNAs were found, indicating the presence of at least two MHC class I loci. Analysis of these four cDNAs and all previously published BoLA cDNA sequences suggested that there may be three cattle MHC class I loci. Additionally, comparison of all of the BoLA class I cDNAs to MHC class I cDNAs of other artiodactyls showed that some of the BoLA class I cDNAs were more similar to certain sheep cDNAs than they were to other cattle cDNAs. These data indicate that each BoLA class I locus has evolved independently after an ancestral gene duplication event and that inter-locus segmental exchange o or concerted evolution has not occurred rapidly enough to cause extensive divergence between the orthologous MHC class I loci of sheep and cattle.
| Original language | English |
|---|---|
| Pages (from-to) | 11-20 |
| Number of pages | 10 |
| Journal | Immunogenetics |
| Volume | 38 |
| Issue number | 1 |
| DOIs | |
| State | Published - Mar 1 1993 |
| Externally published | Yes |
Fingerprint
ASJC Scopus subject areas
- Immunology
- Genetics
Cite this
Sequence and evolution of cattle MHC class I cDNAs : concerted evolution has not taken place in cattle. / Garber, Theodore L.; Hughes, Austin L.; Letvin, Norman L.; Templeton, Joe W.; Watkins, David.
In: Immunogenetics, Vol. 38, No. 1, 01.03.1993, p. 11-20.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Sequence and evolution of cattle MHC class I cDNAs
T2 - concerted evolution has not taken place in cattle
AU - Garber, Theodore L.
AU - Hughes, Austin L.
AU - Letvin, Norman L.
AU - Templeton, Joe W.
AU - Watkins, David
PY - 1993/3/1
Y1 - 1993/3/1
N2 - To explore genetic mechanisms responsible for major histocompatibility complex (MHC) class I evolution in the artiodactyls, we cloned and sequenced MHC class I cDNAs from a Bos taurus bull heterozygous for cattle MHC (BoLA) class I serological specificities w2 and w30. Four unique cDNAs were found, indicating the presence of at least two MHC class I loci. Analysis of these four cDNAs and all previously published BoLA cDNA sequences suggested that there may be three cattle MHC class I loci. Additionally, comparison of all of the BoLA class I cDNAs to MHC class I cDNAs of other artiodactyls showed that some of the BoLA class I cDNAs were more similar to certain sheep cDNAs than they were to other cattle cDNAs. These data indicate that each BoLA class I locus has evolved independently after an ancestral gene duplication event and that inter-locus segmental exchange o or concerted evolution has not occurred rapidly enough to cause extensive divergence between the orthologous MHC class I loci of sheep and cattle.
AB - To explore genetic mechanisms responsible for major histocompatibility complex (MHC) class I evolution in the artiodactyls, we cloned and sequenced MHC class I cDNAs from a Bos taurus bull heterozygous for cattle MHC (BoLA) class I serological specificities w2 and w30. Four unique cDNAs were found, indicating the presence of at least two MHC class I loci. Analysis of these four cDNAs and all previously published BoLA cDNA sequences suggested that there may be three cattle MHC class I loci. Additionally, comparison of all of the BoLA class I cDNAs to MHC class I cDNAs of other artiodactyls showed that some of the BoLA class I cDNAs were more similar to certain sheep cDNAs than they were to other cattle cDNAs. These data indicate that each BoLA class I locus has evolved independently after an ancestral gene duplication event and that inter-locus segmental exchange o or concerted evolution has not occurred rapidly enough to cause extensive divergence between the orthologous MHC class I loci of sheep and cattle.
UR - http://www.scopus.com/inward/record.url?scp=0027475102&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0027475102&partnerID=8YFLogxK
U2 - 10.1007/BF00216385
DO - 10.1007/BF00216385
M3 - Article
C2 - 8462989
AN - SCOPUS:0027475102
VL - 38
SP - 11
EP - 20
JO - Immunogenetics
JF - Immunogenetics
SN - 0093-7711
IS - 1
ER -