Sensory function at diagnosis and in early stages of NIDDM in patients detected through screening

Jay M Sosenko, Marta Kato, Ramon Soto, Ronald B Goldberg

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

OBJECTIVE - We studied whether sensory function abnormalities are present at diagnosis and whether they develop in the early stages of non-insulin-dependent diabetes (NIDDM). RESEARCH DESIGN AND METHODS - Quantitative assessments of vibration sensitivity at the hallux and index fingers, and thermal sensitivity at the hallux were performed at screening (2-h oral glucose tolerance tests) for diabetes in 364 individuals. Twenty-five subjects diagnosed with NIDDM and 25 matched nondiabetic subjects were restudied after an interval of 12-41 mo. RESULTS - When those with NIDDM (n = 41) or impaired glucose tolerance (IGT) (n = 38) were compared with nondiabetic subjects, there were no significant differences in sensory function indices. However, the vibration threshold and HbA1c were related among those found to be hyperglycemic (IGT and NIDDM combined P < 0.05; NIDDM alone P < 0.05). Among diabetic subjects, the vibration threshold and interaction term of height and HbA1c were positively related in a multiple regression analysis (P < 0.01). There were increments in all sensory thresholds in diabetic patients at follow-up (P < 0.05 for all). Increments were smaller in control subjects. CONCLUSIONS - These data suggest that although sensory function tends to be normal at diagnosis in NIDDM patients, there appears to be a diminution in sensory function as the disease progresses. An interaction between metabolic factors and height may influence sensory function early in the course of NIDDM.

Original languageEnglish
Pages (from-to)847-852
Number of pages6
JournalDiabetes Care
Volume15
Issue number7
StatePublished - Jul 1 1992

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Type 2 Diabetes Mellitus
Vibration
Hallux
Glucose Intolerance
Sensory Thresholds
Glucose Tolerance Test
Fingers
Research Design
Hot Temperature
Regression Analysis

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

Cite this

Sensory function at diagnosis and in early stages of NIDDM in patients detected through screening. / Sosenko, Jay M; Kato, Marta; Soto, Ramon; Goldberg, Ronald B.

In: Diabetes Care, Vol. 15, No. 7, 01.07.1992, p. 847-852.

Research output: Contribution to journalArticle

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