Sensitization to myelin basic protein in attacks of multiple sclerosis. A preliminary report

William Sheremata, D. D. Wood, A. A. Moscarello, J. B R Cosgrove

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Recent attempts to detect the presence of antibody to encephalitogenic basic protein in multiple sclerosis have generally been unsuccessful. The utilization of a new system of double immunodiffusion in detecting such antibody in EAE serum prompted us to apply this method in the search of such antibody MS sera. In our preliminary investigation of 67 sera, antibody was detectable in MS sera, but it was most often found during convalescence rather than an acute exacerbation of illness. Antibody was also found in several myasthenic patients, and occasionally in subjects with other neurological disease.

Original languageEnglish
Pages (from-to)165-170
Number of pages6
JournalJournal of the Neurological Sciences
Volume36
Issue number2
DOIs
StatePublished - Jan 1 1978
Externally publishedYes

Fingerprint

Myelin Basic Protein
Multiple Sclerosis
Antibodies
Serum
Immunodiffusion
Muscle Weakness
Proteins

ASJC Scopus subject areas

  • Aging
  • Clinical Neurology
  • Surgery
  • Neuroscience(all)
  • Developmental Neuroscience
  • Neurology

Cite this

Sensitization to myelin basic protein in attacks of multiple sclerosis. A preliminary report. / Sheremata, William; Wood, D. D.; Moscarello, A. A.; Cosgrove, J. B R.

In: Journal of the Neurological Sciences, Vol. 36, No. 2, 01.01.1978, p. 165-170.

Research output: Contribution to journalArticle

Sheremata, William ; Wood, D. D. ; Moscarello, A. A. ; Cosgrove, J. B R. / Sensitization to myelin basic protein in attacks of multiple sclerosis. A preliminary report. In: Journal of the Neurological Sciences. 1978 ; Vol. 36, No. 2. pp. 165-170.
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