Sensibilizzazione ai conservanti contenuti nei cosmetici

Translated title of the contribution: Sensitization due to preservatives in cosmetics

Stylianos Voudouris, Simonetta Silvani, Tommaso Bianchi, Massimiliano Pazzaglia, Antonella Tosti

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Background: preservatives in cosmetics are an important cause of contact allergy. Our study had evaluated the prevalence of sensitization to the most common preservatives in cosmetic products: methyldibromoglutaronitrile/ phenoxyethanol (Euxyl K400®), methyl(chloro)isothiazolinone (Kathon CG®), formaldehyde, parabens, Quaternium 15®, imidazolidinyl urea. Methods: from January 2000 to June 2003, 2591 patients with suspected allergic contact dermatitis were tested with 34 haptens, including those of SIDAPA standard series. Results: 262 patients, 162 females and 100 males, were positive to at least one of the preservatives tested. The sites most frequently affected were hands, trunk and face. The highest rate of positive reactions were found to Euxyl K400® (5.9%) followed, in decreasing order, by Kathon CG® (4.0%), formaldehyde (1.4%), parabens (0.9%), Quaternium 15®, (0.7%), and imidazolidinyl urea (0.3%). Conclusions: our results, slightly higher than those reported in the literature, show the increasing trend of Euxyl K400® and the constant trend of the other 5 preservatives.

Translated title of the contributionSensitization due to preservatives in cosmetics
Original languageItalian
Pages (from-to)16-19
Number of pages4
JournalAnnali Italiani di Dermatologia Clinica e Sperimentale
Issue number1
StatePublished - Jan 1 2004
Externally publishedYes


  • Allergic contact dermatitis
  • Cosmetics
  • Euxyl K400®
  • Formaldehyde
  • Imidazolidinyl urea
  • Kathon CG®
  • Parabens
  • Preservatives
  • Quaternium 15®

ASJC Scopus subject areas

  • Dermatology


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