Sensitivity to Glucocorticoids in Primary Open-Angle Glaucoma

John F. Bigger, Paul F. Palmberg, Harry Zink, Bernard Becker

Research output: Contribution to journalLetter

5 Scopus citations

Abstract

To the Editor: The article by Dr. Claman on “Corticosteroids and Lymphoid Cells” (N Engl J Med 287:388, 1972) alluded to the possibility of heterogeneity of glucocorticoid-lymphoid-cell interactions within a single species. Heterogeneity of response to glucocorticoids in man has been demonstrated in studies of the intraocular pressure response after application of dexamethasone topically to the human eye,1 and by dose,responsecurve testing of dexamethasone-induced suppression of plasma cortisol.2 In both situations it has been shown that people with primary open-angle glaucoma have an increased sensitivity to glucocorticoids. On the basis of observations that glucocorticoids inhibit the transformation of human lymphocytes.

Original languageEnglish (US)
Number of pages1
JournalNew England Journal of Medicine
Volume287
Issue number19
DOIs
StatePublished - Nov 9 1972
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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