Sensitivity of human pancreatic carcinoma cell line (MIA PaCa-2) to Bisantrene and Theprubicin in vitro

George Fountzilas; Lori O. Lim; Adel A. Yunis

doi:10.1007/BF02618873

Sensitivity of human pancreatic carcinoma cell line (MIA PaCa-2) to Bisantrene and Theprubicin in vitro

George Fountzilas, Lori O. Lim, Adel A. Yunis

Medicine

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

We tested the effect of Bisantrene (BS) and Theprubicin (THP-ADR) on cell growth of a human pancreatic carcinoma cell line (MIA PaCa-2). After 1 h exposure ID₅₀ of BS or THP-ADR was 3×10⁻⁷ and 5×10⁻⁸M, respectively. Increasing the exposure time from 1 h to continuous exposure for 5d resulted in 11-fold decrease in ID₅₀ for BS and a 6-fold decrease for THP-ADR. Both drugs inhibited [¹⁴C]thymidine incorporation to the same extent and caused an accumulation of cells into G₂+M phase of the cell cycle.

Original language	English (US)
Pages (from-to)	685-691
Number of pages	7
Journal	In Vitro
Volume	20
Issue number	9
DOIs	https://doi.org/10.1007/BF02618873
State	Published - Sep 1984

Keywords

Bisantrene
Theprubicin
pancreatic cancer
pancreatic carcinoma MIA PaCa-2 cell line

ASJC Scopus subject areas

Biotechnology
Plant Science

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10.1007/BF02618873

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title = "Sensitivity of human pancreatic carcinoma cell line (MIA PaCa-2) to Bisantrene and Theprubicin in vitro",

abstract = "We tested the effect of Bisantrene (BS) and Theprubicin (THP-ADR) on cell growth of a human pancreatic carcinoma cell line (MIA PaCa-2). After 1 h exposure ID50 of BS or THP-ADR was 3×10−7 and 5×10−8M, respectively. Increasing the exposure time from 1 h to continuous exposure for 5d resulted in 11-fold decrease in ID50 for BS and a 6-fold decrease for THP-ADR. Both drugs inhibited [14C]thymidine incorporation to the same extent and caused an accumulation of cells into G2+M phase of the cell cycle.",

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author = "George Fountzilas and Lim, {Lori O.} and Yunis, {Adel A.}",

year = "1984",

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T1 - Sensitivity of human pancreatic carcinoma cell line (MIA PaCa-2) to Bisantrene and Theprubicin in vitro

AU - Fountzilas, George

AU - Lim, Lori O.

AU - Yunis, Adel A.

PY - 1984/9

Y1 - 1984/9

N2 - We tested the effect of Bisantrene (BS) and Theprubicin (THP-ADR) on cell growth of a human pancreatic carcinoma cell line (MIA PaCa-2). After 1 h exposure ID50 of BS or THP-ADR was 3×10−7 and 5×10−8M, respectively. Increasing the exposure time from 1 h to continuous exposure for 5d resulted in 11-fold decrease in ID50 for BS and a 6-fold decrease for THP-ADR. Both drugs inhibited [14C]thymidine incorporation to the same extent and caused an accumulation of cells into G2+M phase of the cell cycle.

AB - We tested the effect of Bisantrene (BS) and Theprubicin (THP-ADR) on cell growth of a human pancreatic carcinoma cell line (MIA PaCa-2). After 1 h exposure ID50 of BS or THP-ADR was 3×10−7 and 5×10−8M, respectively. Increasing the exposure time from 1 h to continuous exposure for 5d resulted in 11-fold decrease in ID50 for BS and a 6-fold decrease for THP-ADR. Both drugs inhibited [14C]thymidine incorporation to the same extent and caused an accumulation of cells into G2+M phase of the cell cycle.

KW - Bisantrene

KW - Theprubicin

KW - pancreatic cancer

KW - pancreatic carcinoma MIA PaCa-2 cell line

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Sensitivity of human pancreatic carcinoma cell line (MIA PaCa-2) to Bisantrene and Theprubicin in vitro

Abstract

Keywords

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