Sensitivity of human pancreatic carcinoma cell line (MIA PaCa-2) to Bisantrene and Theprubicin in vitro

George Fountzilas, Lori O. Lim, Adel A. Yunis

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

We tested the effect of Bisantrene (BS) and Theprubicin (THP-ADR) on cell growth of a human pancreatic carcinoma cell line (MIA PaCa-2). After 1 h exposure ID50 of BS or THP-ADR was 3×10−7 and 5×10−8M, respectively. Increasing the exposure time from 1 h to continuous exposure for 5d resulted in 11-fold decrease in ID50 for BS and a 6-fold decrease for THP-ADR. Both drugs inhibited [14C]thymidine incorporation to the same extent and caused an accumulation of cells into G2+M phase of the cell cycle.

Original languageEnglish (US)
Pages (from-to)685-691
Number of pages7
JournalIn Vitro
Volume20
Issue number9
DOIs
StatePublished - Sep 1984

Keywords

  • Bisantrene
  • Theprubicin
  • pancreatic cancer
  • pancreatic carcinoma MIA PaCa-2 cell line

ASJC Scopus subject areas

  • Biotechnology
  • Plant Science

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