Semiportable electrochemical instrument for determining carbon monoxide in breath

H. J. Vreman; D. K. Stevenson; W. Oh; A. A. Fanaroff; L. L. Wright; J. A. Lemons; E. Wright; S. Shankaran; J. E. Tyson; S. B. Korones; C. R. Bauer; B. J. Stoll; L. A. Papile; E. F. Donovan; R. A. Ehrenkranz

doi:10.1093/clinchem/40.10.1927

Semiportable electrochemical instrument for determining carbon monoxide in breath

H. J. Vreman, D. K. Stevenson, W. Oh, A. A. Fanaroff, L. L. Wright, J. A. Lemons, E. Wright, S. Shankaran, J. E. Tyson, S. B. Korones, C. R. Bauer, B. J. Stoll, L. A. Papile, E. F. Donovan, R. A. Ehrenkranz

Research output: Contribution to journal › Article › peer-review

64 Scopus citations

Abstract

Measurements of carbon monoxide (CO) in breath can be used for the diagnosis of hemolytic disease. A small, semiportable, easy-to-operate CO instrument was developed at Stanford University and tested at 12 Neonatal Research Network Centers of the National Institute of Child Health and Human Development. A syringe pump delivers 7.7 mL of sample per minute through an activated carbon filter to an electrochemical (EC) sensor having a sensitivity of 0.10 ± 0.01 V per 1 μL/L CO in air. The electronically processed sensor signal is displayed on a digital multimeter. For a typical end-tidal CO measurement, corrected for inhaled CO, three 10- to 12-mL breath and room air samples are manually or mechanically collected and analyzed. CO determination in breath samples from 108 healthy, 1 -day-old infants of nonsmoking mothers compared favorably with determinations by gas chromatography (GC), 1.3 ± 0.8 vs 1.2 ± 0.8 (mean ± SD), respectively, with a regression equation of EC = 0.95 GC + 0.13 (r² = 0.98). The results demonstrate that the EC-CO instrument yields results that are comparable with those obtained by the more difficult to perform GC assay.

Original language	English (US)
Pages (from-to)	1927-1933
Number of pages	7
Journal	Clinical chemistry
Volume	40
Issue number	10
DOIs	https://doi.org/10.1093/clinchem/40.10.1927
State	Published - 1994
Externally published	Yes

Keywords

End-tidal breath analysis
Gas chromatography compared
Hyperbilirubinemia
Jaundice
Neonates

ASJC Scopus subject areas

Clinical Biochemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1093/clinchem/40.10.1927

Cite this

Vreman, H. J., Stevenson, D. K., Oh, W., Fanaroff, A. A., Wright, L. L., Lemons, J. A., Wright, E., Shankaran, S., Tyson, J. E., Korones, S. B., Bauer, C. R., Stoll, B. J., Papile, L. A., Donovan, E. F., & Ehrenkranz, R. A. (1994). Semiportable electrochemical instrument for determining carbon monoxide in breath. Clinical chemistry, 40(10), 1927-1933. https://doi.org/10.1093/clinchem/40.10.1927

Semiportable electrochemical instrument for determining carbon monoxide in breath. / Vreman, H. J.; Stevenson, D. K.; Oh, W.; Fanaroff, A. A.; Wright, L. L.; Lemons, J. A.; Wright, E.; Shankaran, S.; Tyson, J. E.; Korones, S. B.; Bauer, C. R.; Stoll, B. J.; Papile, L. A.; Donovan, E. F.; Ehrenkranz, R. A.

In: Clinical chemistry, Vol. 40, No. 10, 1994, p. 1927-1933.

Research output: Contribution to journal › Article › peer-review

Vreman, HJ, Stevenson, DK, Oh, W, Fanaroff, AA, Wright, LL, Lemons, JA, Wright, E, Shankaran, S, Tyson, JE, Korones, SB, Bauer, CR, Stoll, BJ, Papile, LA, Donovan, EF & Ehrenkranz, RA 1994, 'Semiportable electrochemical instrument for determining carbon monoxide in breath', Clinical chemistry, vol. 40, no. 10, pp. 1927-1933. https://doi.org/10.1093/clinchem/40.10.1927

Vreman, H. J. ; Stevenson, D. K. ; Oh, W. ; Fanaroff, A. A. ; Wright, L. L. ; Lemons, J. A. ; Wright, E. ; Shankaran, S. ; Tyson, J. E. ; Korones, S. B. ; Bauer, C. R. ; Stoll, B. J. ; Papile, L. A. ; Donovan, E. F. ; Ehrenkranz, R. A. / Semiportable electrochemical instrument for determining carbon monoxide in breath. In: Clinical chemistry. 1994 ; Vol. 40, No. 10. pp. 1927-1933.

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abstract = "Measurements of carbon monoxide (CO) in breath can be used for the diagnosis of hemolytic disease. A small, semiportable, easy-to-operate CO instrument was developed at Stanford University and tested at 12 Neonatal Research Network Centers of the National Institute of Child Health and Human Development. A syringe pump delivers 7.7 mL of sample per minute through an activated carbon filter to an electrochemical (EC) sensor having a sensitivity of 0.10 ± 0.01 V per 1 μL/L CO in air. The electronically processed sensor signal is displayed on a digital multimeter. For a typical end-tidal CO measurement, corrected for inhaled CO, three 10- to 12-mL breath and room air samples are manually or mechanically collected and analyzed. CO determination in breath samples from 108 healthy, 1 -day-old infants of nonsmoking mothers compared favorably with determinations by gas chromatography (GC), 1.3 ± 0.8 vs 1.2 ± 0.8 (mean ± SD), respectively, with a regression equation of EC = 0.95 GC + 0.13 (r2 = 0.98). The results demonstrate that the EC-CO instrument yields results that are comparable with those obtained by the more difficult to perform GC assay.",

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KW - Jaundice

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Semiportable electrochemical instrument for determining carbon monoxide in breath

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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