Semiportable electrochemical instrument for determining carbon monoxide in breath

H. J. Vreman; D. K. Stevenson; W. Oh; A. A. Fanaroff; L. L. Wright; J. A. Lemons; E. Wright; S. Shankaran; J. E. Tyson; S. B. Korones; C. R. Bauer; B. J. Stoll; L. A. Papile; E. F. Donovan; R. A. Ehrenkranz

doi:10.1093/clinchem/40.10.1927

Semiportable electrochemical instrument for determining carbon monoxide in breath

H. J. Vreman, D. K. Stevenson, W. Oh, A. A. Fanaroff, L. L. Wright, J. A. Lemons, E. Wright, S. Shankaran, J. E. Tyson, S. B. Korones, C. R. Bauer, B. J. Stoll, L. A. Papile, E. F. Donovan, R. A. Ehrenkranz

Research output: Contribution to journal › Article › peer-review

68 Scopus citations

Abstract

Measurements of carbon monoxide (CO) in breath can be used for the diagnosis of hemolytic disease. A small, semiportable, easy-to-operate CO instrument was developed at Stanford University and tested at 12 Neonatal Research Network Centers of the National Institute of Child Health and Human Development. A syringe pump delivers 7.7 mL of sample per minute through an activated carbon filter to an electrochemical (EC) sensor having a sensitivity of 0.10 ± 0.01 V per 1 μL/L CO in air. The electronically processed sensor signal is displayed on a digital multimeter. For a typical end-tidal CO measurement, corrected for inhaled CO, three 10- to 12-mL breath and room air samples are manually or mechanically collected and analyzed. CO determination in breath samples from 108 healthy, 1 -day-old infants of nonsmoking mothers compared favorably with determinations by gas chromatography (GC), 1.3 ± 0.8 vs 1.2 ± 0.8 (mean ± SD), respectively, with a regression equation of EC = 0.95 GC + 0.13 (r² = 0.98). The results demonstrate that the EC-CO instrument yields results that are comparable with those obtained by the more difficult to perform GC assay.

Original language	English (US)
Pages (from-to)	1927-1933
Number of pages	7
Journal	Clinical chemistry
Volume	40
Issue number	10
DOIs	https://doi.org/10.1093/clinchem/40.10.1927
State	Published - 1994
Externally published	Yes

Keywords

End-tidal breath analysis
Gas chromatography compared
Hyperbilirubinemia
Jaundice
Neonates

ASJC Scopus subject areas

Clinical Biochemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1093/clinchem/40.10.1927

Cite this

Vreman, H. J., Stevenson, D. K., Oh, W., Fanaroff, A. A., Wright, L. L., Lemons, J. A., Wright, E., Shankaran, S., Tyson, J. E., Korones, S. B., Bauer, C. R., Stoll, B. J., Papile, L. A., Donovan, E. F., & Ehrenkranz, R. A. (1994). Semiportable electrochemical instrument for determining carbon monoxide in breath. Clinical chemistry, 40(10), 1927-1933. https://doi.org/10.1093/clinchem/40.10.1927

Semiportable electrochemical instrument for determining carbon monoxide in breath. / Vreman, H. J.; Stevenson, D. K.; Oh, W.; Fanaroff, A. A.; Wright, L. L.; Lemons, J. A.; Wright, E.; Shankaran, S.; Tyson, J. E.; Korones, S. B.; Bauer, C. R.; Stoll, B. J.; Papile, L. A.; Donovan, E. F.; Ehrenkranz, R. A.

In: Clinical chemistry, Vol. 40, No. 10, 1994, p. 1927-1933.

Research output: Contribution to journal › Article › peer-review

Vreman, HJ, Stevenson, DK, Oh, W, Fanaroff, AA, Wright, LL, Lemons, JA, Wright, E, Shankaran, S, Tyson, JE, Korones, SB, Bauer, CR, Stoll, BJ, Papile, LA, Donovan, EF & Ehrenkranz, RA 1994, 'Semiportable electrochemical instrument for determining carbon monoxide in breath', Clinical chemistry, vol. 40, no. 10, pp. 1927-1933. https://doi.org/10.1093/clinchem/40.10.1927

Vreman, H. J. ; Stevenson, D. K. ; Oh, W. ; Fanaroff, A. A. ; Wright, L. L. ; Lemons, J. A. ; Wright, E. ; Shankaran, S. ; Tyson, J. E. ; Korones, S. B. ; Bauer, C. R. ; Stoll, B. J. ; Papile, L. A. ; Donovan, E. F. ; Ehrenkranz, R. A. / Semiportable electrochemical instrument for determining carbon monoxide in breath. In: Clinical chemistry. 1994 ; Vol. 40, No. 10. pp. 1927-1933.

@article{bbee21624f2047cdb3cf5bbdc1e8b088,

title = "Semiportable electrochemical instrument for determining carbon monoxide in breath",

abstract = "Measurements of carbon monoxide (CO) in breath can be used for the diagnosis of hemolytic disease. A small, semiportable, easy-to-operate CO instrument was developed at Stanford University and tested at 12 Neonatal Research Network Centers of the National Institute of Child Health and Human Development. A syringe pump delivers 7.7 mL of sample per minute through an activated carbon filter to an electrochemical (EC) sensor having a sensitivity of 0.10 ± 0.01 V per 1 μL/L CO in air. The electronically processed sensor signal is displayed on a digital multimeter. For a typical end-tidal CO measurement, corrected for inhaled CO, three 10- to 12-mL breath and room air samples are manually or mechanically collected and analyzed. CO determination in breath samples from 108 healthy, 1 -day-old infants of nonsmoking mothers compared favorably with determinations by gas chromatography (GC), 1.3 ± 0.8 vs 1.2 ± 0.8 (mean ± SD), respectively, with a regression equation of EC = 0.95 GC + 0.13 (r2 = 0.98). The results demonstrate that the EC-CO instrument yields results that are comparable with those obtained by the more difficult to perform GC assay.",

keywords = "End-tidal breath analysis, Gas chromatography compared, Hyperbilirubinemia, Jaundice, Neonates",

author = "Vreman, {H. J.} and Stevenson, {D. K.} and W. Oh and Fanaroff, {A. A.} and Wright, {L. L.} and Lemons, {J. A.} and E. Wright and S. Shankaran and Tyson, {J. E.} and Korones, {S. B.} and Bauer, {C. R.} and Stoll, {B. J.} and Papile, {L. A.} and Donovan, {E. F.} and Ehrenkranz, {R. A.}",

year = "1994",

doi = "10.1093/clinchem/40.10.1927",

language = "English (US)",

volume = "40",

pages = "1927--1933",

journal = "Clinical Chemistry",

issn = "0009-9147",

publisher = "American Association for Clinical Chemistry Inc.",

number = "10",

}

TY - JOUR

T1 - Semiportable electrochemical instrument for determining carbon monoxide in breath

AU - Vreman, H. J.

AU - Stevenson, D. K.

AU - Oh, W.

AU - Fanaroff, A. A.

AU - Wright, L. L.

AU - Lemons, J. A.

AU - Wright, E.

AU - Shankaran, S.

AU - Tyson, J. E.

AU - Korones, S. B.

AU - Bauer, C. R.

AU - Stoll, B. J.

AU - Papile, L. A.

AU - Donovan, E. F.

AU - Ehrenkranz, R. A.

PY - 1994

Y1 - 1994

N2 - Measurements of carbon monoxide (CO) in breath can be used for the diagnosis of hemolytic disease. A small, semiportable, easy-to-operate CO instrument was developed at Stanford University and tested at 12 Neonatal Research Network Centers of the National Institute of Child Health and Human Development. A syringe pump delivers 7.7 mL of sample per minute through an activated carbon filter to an electrochemical (EC) sensor having a sensitivity of 0.10 ± 0.01 V per 1 μL/L CO in air. The electronically processed sensor signal is displayed on a digital multimeter. For a typical end-tidal CO measurement, corrected for inhaled CO, three 10- to 12-mL breath and room air samples are manually or mechanically collected and analyzed. CO determination in breath samples from 108 healthy, 1 -day-old infants of nonsmoking mothers compared favorably with determinations by gas chromatography (GC), 1.3 ± 0.8 vs 1.2 ± 0.8 (mean ± SD), respectively, with a regression equation of EC = 0.95 GC + 0.13 (r2 = 0.98). The results demonstrate that the EC-CO instrument yields results that are comparable with those obtained by the more difficult to perform GC assay.

AB - Measurements of carbon monoxide (CO) in breath can be used for the diagnosis of hemolytic disease. A small, semiportable, easy-to-operate CO instrument was developed at Stanford University and tested at 12 Neonatal Research Network Centers of the National Institute of Child Health and Human Development. A syringe pump delivers 7.7 mL of sample per minute through an activated carbon filter to an electrochemical (EC) sensor having a sensitivity of 0.10 ± 0.01 V per 1 μL/L CO in air. The electronically processed sensor signal is displayed on a digital multimeter. For a typical end-tidal CO measurement, corrected for inhaled CO, three 10- to 12-mL breath and room air samples are manually or mechanically collected and analyzed. CO determination in breath samples from 108 healthy, 1 -day-old infants of nonsmoking mothers compared favorably with determinations by gas chromatography (GC), 1.3 ± 0.8 vs 1.2 ± 0.8 (mean ± SD), respectively, with a regression equation of EC = 0.95 GC + 0.13 (r2 = 0.98). The results demonstrate that the EC-CO instrument yields results that are comparable with those obtained by the more difficult to perform GC assay.

KW - End-tidal breath analysis

KW - Gas chromatography compared

KW - Hyperbilirubinemia

KW - Jaundice

KW - Neonates

UR - http://www.scopus.com/inward/record.url?scp=0028089756&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028089756&partnerID=8YFLogxK

U2 - 10.1093/clinchem/40.10.1927

DO - 10.1093/clinchem/40.10.1927

M3 - Article

C2 - 7923774

AN - SCOPUS:0028089756

VL - 40

SP - 1927

EP - 1933

JO - Clinical Chemistry

JF - Clinical Chemistry

SN - 0009-9147

IS - 10

ER -

Semiportable electrochemical instrument for determining carbon monoxide in breath

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this