Semantic interference in mild Alzheimer disease: Preliminary findings

David Loewenstein, Amarilis Acevedo, Lynn Schram, Raymond Ownby, Gloria White, Brian Mogosky, William W. Barker, Ranjan Duara

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Objective: The authors evaluated the usefulness and psychometric properties of the Semantic Interference Test (SIT) in patients with mild Alzheimer disease (AD). Methods: Subjects were first presented with 10 common objects to be learned over three trials. Proactive interference was assessed by having subjects recall 10 new objects that were semantically related to the previous ones. Retroactive interference was assessed by having subjects recall the original 10 objects. Results: Controlling for overall memory impairment, very mildly impaired AD patients demonstrated significantly greater proactive and retroactive interference effects than the normal, community-dwelling comparison group. The proactive score alone and the combined proactive-plus-retroactive score index were more effective than traditional neuropsychological measures of delayed recall in distinguishing between the very mildly impaired AD group and the normal-comparison group. Conclusion: The authors discuss the potential usefulness of the SIT in identifying vulnerability to semantic interference in early AD.

Original languageEnglish
Pages (from-to)252-255
Number of pages4
JournalAmerican Journal of Geriatric Psychiatry
Volume11
Issue number2
DOIs
StatePublished - Jan 1 2003

Fingerprint

Semantics
Alzheimer Disease
Independent Living
Psychometrics

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Geriatrics and Gerontology

Cite this

Semantic interference in mild Alzheimer disease : Preliminary findings. / Loewenstein, David; Acevedo, Amarilis; Schram, Lynn; Ownby, Raymond; White, Gloria; Mogosky, Brian; Barker, William W.; Duara, Ranjan.

In: American Journal of Geriatric Psychiatry, Vol. 11, No. 2, 01.01.2003, p. 252-255.

Research output: Contribution to journalArticle

Loewenstein, D, Acevedo, A, Schram, L, Ownby, R, White, G, Mogosky, B, Barker, WW & Duara, R 2003, 'Semantic interference in mild Alzheimer disease: Preliminary findings', American Journal of Geriatric Psychiatry, vol. 11, no. 2, pp. 252-255. https://doi.org/10.1097/00019442-200303000-00017
Loewenstein, David ; Acevedo, Amarilis ; Schram, Lynn ; Ownby, Raymond ; White, Gloria ; Mogosky, Brian ; Barker, William W. ; Duara, Ranjan. / Semantic interference in mild Alzheimer disease : Preliminary findings. In: American Journal of Geriatric Psychiatry. 2003 ; Vol. 11, No. 2. pp. 252-255.
@article{1eeeabeec5dd4cc88f87b8fa8165174b,
title = "Semantic interference in mild Alzheimer disease: Preliminary findings",
abstract = "Objective: The authors evaluated the usefulness and psychometric properties of the Semantic Interference Test (SIT) in patients with mild Alzheimer disease (AD). Methods: Subjects were first presented with 10 common objects to be learned over three trials. Proactive interference was assessed by having subjects recall 10 new objects that were semantically related to the previous ones. Retroactive interference was assessed by having subjects recall the original 10 objects. Results: Controlling for overall memory impairment, very mildly impaired AD patients demonstrated significantly greater proactive and retroactive interference effects than the normal, community-dwelling comparison group. The proactive score alone and the combined proactive-plus-retroactive score index were more effective than traditional neuropsychological measures of delayed recall in distinguishing between the very mildly impaired AD group and the normal-comparison group. Conclusion: The authors discuss the potential usefulness of the SIT in identifying vulnerability to semantic interference in early AD.",
author = "David Loewenstein and Amarilis Acevedo and Lynn Schram and Raymond Ownby and Gloria White and Brian Mogosky and Barker, {William W.} and Ranjan Duara",
year = "2003",
month = "1",
day = "1",
doi = "10.1097/00019442-200303000-00017",
language = "English",
volume = "11",
pages = "252--255",
journal = "American Journal of Geriatric Psychiatry",
issn = "1064-7481",
publisher = "Lippincott Williams and Wilkins",
number = "2",

}

TY - JOUR

T1 - Semantic interference in mild Alzheimer disease

T2 - Preliminary findings

AU - Loewenstein, David

AU - Acevedo, Amarilis

AU - Schram, Lynn

AU - Ownby, Raymond

AU - White, Gloria

AU - Mogosky, Brian

AU - Barker, William W.

AU - Duara, Ranjan

PY - 2003/1/1

Y1 - 2003/1/1

N2 - Objective: The authors evaluated the usefulness and psychometric properties of the Semantic Interference Test (SIT) in patients with mild Alzheimer disease (AD). Methods: Subjects were first presented with 10 common objects to be learned over three trials. Proactive interference was assessed by having subjects recall 10 new objects that were semantically related to the previous ones. Retroactive interference was assessed by having subjects recall the original 10 objects. Results: Controlling for overall memory impairment, very mildly impaired AD patients demonstrated significantly greater proactive and retroactive interference effects than the normal, community-dwelling comparison group. The proactive score alone and the combined proactive-plus-retroactive score index were more effective than traditional neuropsychological measures of delayed recall in distinguishing between the very mildly impaired AD group and the normal-comparison group. Conclusion: The authors discuss the potential usefulness of the SIT in identifying vulnerability to semantic interference in early AD.

AB - Objective: The authors evaluated the usefulness and psychometric properties of the Semantic Interference Test (SIT) in patients with mild Alzheimer disease (AD). Methods: Subjects were first presented with 10 common objects to be learned over three trials. Proactive interference was assessed by having subjects recall 10 new objects that were semantically related to the previous ones. Retroactive interference was assessed by having subjects recall the original 10 objects. Results: Controlling for overall memory impairment, very mildly impaired AD patients demonstrated significantly greater proactive and retroactive interference effects than the normal, community-dwelling comparison group. The proactive score alone and the combined proactive-plus-retroactive score index were more effective than traditional neuropsychological measures of delayed recall in distinguishing between the very mildly impaired AD group and the normal-comparison group. Conclusion: The authors discuss the potential usefulness of the SIT in identifying vulnerability to semantic interference in early AD.

UR - http://www.scopus.com/inward/record.url?scp=0037369629&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0037369629&partnerID=8YFLogxK

U2 - 10.1097/00019442-200303000-00017

DO - 10.1097/00019442-200303000-00017

M3 - Article

C2 - 12611756

AN - SCOPUS:0037369629

VL - 11

SP - 252

EP - 255

JO - American Journal of Geriatric Psychiatry

JF - American Journal of Geriatric Psychiatry

SN - 1064-7481

IS - 2

ER -