Self-Reported Long-Term Antiretroviral Adherence: A Longitudinal Study Among HIV Infected Pregnant Women in Mpumalanga, South Africa

Shandir Ramlagan, Violeta J. Rodriguez, Karl Peltzer, Robert A.C. Ruiter, Deborah L. Jones, Sibusiso Sifunda

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

We evaluate the impact of a multi-session cognitive behavioral prevention of mother to child transmission (PMTCT) intervention on antiretroviral therapy (ART) adherence. A total of 683 women were enrolled into a randomized control trial conducted at twelve community health centres (CHCs) in Mpumalanga Province. Participants were randomized to Standard Care or Enhanced PMTCT Intervention (EI). EI received three group and three individual intervention sessions. EI impact was ascertained on ART adherence (baseline vs 12 months post-partum). Women in the intervention groups were less likely to remain stable with regards to ART adherence over time compared to the control groups. In predicting if women become adherent over time, the intervention condition had no impact. However, the intervention condition was significantly positively associated with change to non-adherence. The enhanced cognitive-behavioral PMTCT intervention did not show any improvement in relation to maternal ART adherence relative to standard PMTCT care. Trial registration Clinicaltrials.gov: number NCT02085356.

Original languageEnglish (US)
Pages (from-to)2576-2587
Number of pages12
JournalAIDS and Behavior
Volume23
Issue number9
DOIs
StatePublished - Sep 1 2019

Keywords

  • ART adherence
  • Maternal
  • Pregnancy
  • Randomized Control Trial
  • South Africa

ASJC Scopus subject areas

  • Social Psychology
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

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