Self-Reported Depression and Duodenal Cortisol Biomarkers Are Related to Weight Loss in Young Metabolic and Bariatric Surgery Patients

Sarah E. Messiah, Denise C. Vidot, Christine Spadola, Smita Joel, Sapna Dao, Sylvia Daunert, Melissa Cuesta, Nestor De La Cruz-Muñoz

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Abnormal cortisol and serotonin concentrations are reported in obese, anxious, and/or depressed individuals. We examined how duodenal levels of these hormones correlated with self-reported anxiety and depression and their individual and combined contribution to weight loss among young metabolic and bariatric surgery (MBS) patients. Methods: Patients ≤30 years of age who had scheduled MBS were recruited. Weight, depression, and anxiety were collected within 2 weeks before MBS, and weight was again collected 6-months post-MBS. Duodenum serotonin and cortisol tissue samples were collected during MBS. Results: The majority of the sample (N = 18, mean age 23.6 years, standard deviation: 4.8 years) was female (72.2%) and Hispanic (66.7%), and 33.3% were non-Hispanic black. Duodenum cortisol (pg/mL) was inversely correlated with the Beck Anxiety Inventory (r = -0.76, p = 0.04) and Beck Depression Inventory (BDI)-II (r = -0.83, p = 0.02). For every pg/mL increase in the amount of (tissue) cortisol plus BDI-II, the score showed a 0.029 pound increase post-MBS (p = 0.02). Conversely, after adjusting for age every unit increase in BDI-II score showed a 1.83 pound decrease post-MBS (p = 0.03). Conclusions: A combined effect of cortisol and depression had a significant effect on weight loss, while depression was independently associated with weight gain. Longitudinal biospecimen collection would add information to these complex relationships.

Original languageEnglish (US)
Pages (from-to)73-80
Number of pages8
JournalBariatric Surgical Practice and Patient Care
Volume15
Issue number2
DOIs
StatePublished - Jun 2020

Keywords

  • anxiety
  • bariatric
  • cortisol
  • depression
  • duodenum
  • serotonin

ASJC Scopus subject areas

  • Surgery
  • Nutrition and Dietetics
  • Medical–Surgical

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