Self-report of cognitive impairment and mini-mental state examination performance in PRKN, LRRK2, and GBA carriers with early onset Parkinson's disease

Roy N. Alcalay, Helen Mejia-Santana, Ming X. Tang, Brian Rakitin, Llency Rosado, Barbara Ross, Miguel Verbitsky, Sergey Kisselev, Elan D. Louis, Cynthia L. Comella, Amy Colcher, Danna Jennings, Martha A. Nance, Susan Bressman, William K. Scott, Caroline Tanner, Susan F. Mickel, Howard F. Andrews, Cheryl H. Waters, Stanley FahnLucien J. Cote, Steven J. Frucht, Blair Ford, Michael Rezak, Kevin Novak, Joseph H. Friedman, Ronald Pfeiffer, Laura Marsh, Bradley Hiner, Andrew Siderowf, Ruth Ottman, Lorraine N. Clark, Karen S. Marder, Elise Caccappolo

Research output: Contribution to journalArticle

37 Scopus citations

Abstract

While little is known about risk factors for cognitive impairment in early onset Parkinson disease (EOPD), postmortem studies have shown an association between dementia with Lewy bodies (DLB) and glucocerebrosidase (GBA) mutation. We compared Mini-Mental State Examination (MMSE) performance and self-reported cognitive impairment in 699 EOPD participants genotyped for mutations in parkin (PRKN), leucine-rich repeat kinase-2 (LRRK2), and GBA. Logistic regression was used to assess the association between reported cognitive impairment and MMSE score, as well as between GBA group membership and self-reported impairment and MMSE. GBA carriers reported more impairment, but MMSE performance did not differ among genetic groups. Detailed neuropsychological testing is required to explore the association between cognitive impairment and GBA mutations.

Original languageEnglish (US)
Pages (from-to)775-779
Number of pages5
JournalJournal of Clinical and Experimental Neuropsychology
Volume32
Issue number7
DOIs
StatePublished - Aug 2010

Keywords

  • Cognition
  • Genetics
  • Glucocerebrosidase
  • Leucine-rich repeat kinase-2
  • Mini-mental state examination
  • Parkin
  • Parkinson

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology
  • Clinical Psychology

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    Alcalay, R. N., Mejia-Santana, H., Tang, M. X., Rakitin, B., Rosado, L., Ross, B., Verbitsky, M., Kisselev, S., Louis, E. D., Comella, C. L., Colcher, A., Jennings, D., Nance, M. A., Bressman, S., Scott, W. K., Tanner, C., Mickel, S. F., Andrews, H. F., Waters, C. H., ... Caccappolo, E. (2010). Self-report of cognitive impairment and mini-mental state examination performance in PRKN, LRRK2, and GBA carriers with early onset Parkinson's disease. Journal of Clinical and Experimental Neuropsychology, 32(7), 775-779. https://doi.org/10.1080/13803390903521018