Self-Report and Dry Blood Spot Measurement of Antiretroviral Medications as Markers of Adherence in Pregnant Women in Rural South Africa

Maria L Alcaide, Shandir Ramlagan, Violeta J. Rodriguez, Ryan Cook, Karl Peltzer, Stephen M Weiss, Sibusiso Sifunda, Deborah Jones

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Antiretroviral (ARV) adherence is essential to prevent mother-to-child transmission of HIV. This study compared self-reported adherence versus ARV detection in dried blood spots (DBS) among N = 392 HIV-infected pregnant women in South Africa (SA). Women completed two self-reported adherence measures [visual analog scale (VAS), AIDS Clinical Trials Group Adherence (ACTG)]. Adherence was 89% (VAS), 80% (ACTG), and 74% (DBS). Self-report measures marginally agreed with DBS (VAS: Kappa = 0.101, Area under the ROC curve (AUROC) = 0.543; ACTG: Kappa = 0.081, AUROC = 0.538). Self-reported adherence was overestimated and agreement with DBS was poor. Validation of self-reported ARV adherence among pregnant HIV+ women in SA is needed.

Original languageEnglish (US)
Pages (from-to)1-6
Number of pages6
JournalAIDS and Behavior
DOIs
StateAccepted/In press - Mar 30 2017

Fingerprint

South Africa
Self Report
Pregnant Women
Visual Analog Scale
Acquired Immunodeficiency Syndrome
Clinical Trials
HIV
ROC Curve
Area Under Curve
Mothers

Keywords

  • Adherence
  • Antiretrovirals
  • HIV
  • Measurement
  • South Africa
  • Women

ASJC Scopus subject areas

  • Social Psychology
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

Cite this

Self-Report and Dry Blood Spot Measurement of Antiretroviral Medications as Markers of Adherence in Pregnant Women in Rural South Africa. / Alcaide, Maria L; Ramlagan, Shandir; Rodriguez, Violeta J.; Cook, Ryan; Peltzer, Karl; Weiss, Stephen M; Sifunda, Sibusiso; Jones, Deborah.

In: AIDS and Behavior, 30.03.2017, p. 1-6.

Research output: Contribution to journalArticle

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