Self-Report and Dry Blood Spot Measurement of Antiretroviral Medications as Markers of Adherence in Pregnant Women in Rural South Africa

Maria L. Alcaide, Shandir Ramlagan, Violeta J. Rodriguez, Ryan Cook, Karl Peltzer, Stephen M. Weiss, Sibusiso Sifunda, Deborah L. Jones

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

Antiretroviral (ARV) adherence is essential to prevent mother-to-child transmission of HIV. This study compared self-reported adherence versus ARV detection in dried blood spots (DBS) among N = 392 HIV-infected pregnant women in South Africa (SA). Women completed two self-reported adherence measures [visual analog scale (VAS), AIDS Clinical Trials Group Adherence (ACTG)]. Adherence was 89% (VAS), 80% (ACTG), and 74% (DBS). Self-report measures marginally agreed with DBS (VAS: Kappa = 0.101, Area under the ROC curve (AUROC) = 0.543; ACTG: Kappa = 0.081, AUROC = 0.538). Self-reported adherence was overestimated and agreement with DBS was poor. Validation of self-reported ARV adherence among pregnant HIV+ women in SA is needed.

Original languageEnglish (US)
Pages (from-to)2135-2140
Number of pages6
JournalAIDS and Behavior
Volume21
Issue number7
DOIs
StatePublished - Jul 1 2017

Keywords

  • Adherence
  • Antiretrovirals
  • HIV
  • Measurement
  • South Africa
  • Women

ASJC Scopus subject areas

  • Social Psychology
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

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