Selenium, deiodinases and endocrine function

Antonio C. Bianco, P. Reed Larsen

Research output: Chapter in Book/Report/Conference proceedingChapter

7 Citations (Scopus)

Abstract

The three iodothyronine deiodinases catalyze the initiation (D1, D2) and termination (D3) of THyroid hormone effects in vertebrates. A 3-dimensional model predicts that these enzymes share a similar structural organization and belong to the thioredoxin (TRX) fold superfamily. Their active center is a selenocysteine-containing pocket defined by the β1-α1-β2 motifs of the TRX fold and a domain that shares strong similarities with the active site of iduronidase, a member of the clan GH-A fold of glycoside hydrolases. While D 1 and D3 are long-lived plasma membrane proteins (t 1/2 10-12 h), D2 is an endoplasmic reticulum resident protein that is inactivated by selective conjugation to ubiquitin, a process that is mediated by WSB-1, a Hedgehog-inducible gene. Remarkably, D2 ubiquitination is reversible and activity restored after deubiquitination by the pVHL-interacting deubiquitinating enzymes (VDU1 and VDU2). Deiodinases play a major role in development as well as in adults as critical players in Thyroid hormone homeostasis, particularly during hypo- and hyper Thyroidism. In addition to playing an important part in energy homeostasis, changes in deiodinase activity explain the alterations in Thyroid economy observed during illness and in the recently described syndrome of consumptive hypo Thyroidism.

Original languageEnglish
Title of host publicationSelenium: Its Molecular Biology and Role in Human Health, Second Edition
PublisherSpringer US
Pages207-219
Number of pages13
ISBN (Print)9780387338279, 0387338268, 9780387338262
DOIs
StatePublished - Jan 1 2006

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Iodide Peroxidase
Selenium
Thioredoxins
Thyroid Hormones
Homeostasis
Iduronidase
Selenocysteine
Hedgehogs
Glycoside Hydrolases
Ubiquitination
Ubiquitin
Endoplasmic Reticulum
Vertebrates
Blood Proteins
Catalytic Domain
Thyroid Gland
Membrane Proteins
Cell Membrane
Enzymes
Genes

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Bianco, A. C., & Larsen, P. R. (2006). Selenium, deiodinases and endocrine function. In Selenium: Its Molecular Biology and Role in Human Health, Second Edition (pp. 207-219). Springer US. https://doi.org/10.1007/0-387-33827-6_19

Selenium, deiodinases and endocrine function. / Bianco, Antonio C.; Larsen, P. Reed.

Selenium: Its Molecular Biology and Role in Human Health, Second Edition. Springer US, 2006. p. 207-219.

Research output: Chapter in Book/Report/Conference proceedingChapter

Bianco, AC & Larsen, PR 2006, Selenium, deiodinases and endocrine function. in Selenium: Its Molecular Biology and Role in Human Health, Second Edition. Springer US, pp. 207-219. https://doi.org/10.1007/0-387-33827-6_19
Bianco AC, Larsen PR. Selenium, deiodinases and endocrine function. In Selenium: Its Molecular Biology and Role in Human Health, Second Edition. Springer US. 2006. p. 207-219 https://doi.org/10.1007/0-387-33827-6_19
Bianco, Antonio C. ; Larsen, P. Reed. / Selenium, deiodinases and endocrine function. Selenium: Its Molecular Biology and Role in Human Health, Second Edition. Springer US, 2006. pp. 207-219
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