Selective Loss of [3H]Kainic Acid and [3H]AMPA Binding in Layer VI of Frontal Cortex in Huntington's Disease

Molly V. Wagster, John C. Hedreen, Carol E. Peyser, Susan E. Folstein, Christopher A. Ross

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

Excitatory amino acid neurotoxicity has been proposed to cause the neostriatal neuronal degeneration of Huntington's disease (HD); N -methyl-d-aspartate (NMDA), α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA), and kainate receptors have been hypothesized to play important roles in this process. We have recently reported a loss of neurons in layer VI of the cerebral cortex in HD. Using quantitative autoradiographic methods, we have now measured NMDA, AMPA, and kainate receptor binding in the frontal cerebral cortex of the brains of controls and individuals with HD. We find no change in NMDA receptor binding but a selective decrease in kainate and AMPA receptor binding in layer VI. These data suggest that cerebral cortical neurons possessing kainate or AMPA receptors may be selectively vulnerable in individuals with HD.

Original languageEnglish
Pages (from-to)70-75
Number of pages6
JournalExperimental Neurology
Volume127
Issue number1
DOIs
StatePublished - May 1 1994

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Kainic Acid Receptors
alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid
AMPA Receptors
Kainic Acid
Huntington Disease
Frontal Lobe
Cerebral Cortex
Isoxazoles
Neurons
Excitatory Amino Acids
Aspartic Acid
Brain
aspartic acid receptor

ASJC Scopus subject areas

  • Neurology
  • Neuroscience(all)

Cite this

Selective Loss of [3H]Kainic Acid and [3H]AMPA Binding in Layer VI of Frontal Cortex in Huntington's Disease. / Wagster, Molly V.; Hedreen, John C.; Peyser, Carol E.; Folstein, Susan E.; Ross, Christopher A.

In: Experimental Neurology, Vol. 127, No. 1, 01.05.1994, p. 70-75.

Research output: Contribution to journalArticle

Wagster, Molly V. ; Hedreen, John C. ; Peyser, Carol E. ; Folstein, Susan E. ; Ross, Christopher A. / Selective Loss of [3H]Kainic Acid and [3H]AMPA Binding in Layer VI of Frontal Cortex in Huntington's Disease. In: Experimental Neurology. 1994 ; Vol. 127, No. 1. pp. 70-75.
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