Selective loss of a family of gene transcripts in a hereditary murine cataract

A. T. Garber, C. Winkler, T. Shinohara, C. R. King, George Inana, J. Piatigorsky, R. J. Gold

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

The eye lens of the Fraser mouse contains a dominantly inherited cataract with reduced amounts of seven distinct but homologous γ crystallins encoded by a family of γ-crystallin genes. The results of experiments with cultured lenses, cell-free RNA translation, and Northern blot hybridization indicated a specific loss of the family of γ-crystallin messenger RNA's in the Fraser mouse lens. Southern blot hybridization of genomic DNA's from normal and Fraser mice showed no differences in γ-crystallins coding sequences.

Original languageEnglish
Pages (from-to)74-77
Number of pages4
JournalScience
Volume227
Issue number4682
DOIs
StatePublished - Mar 27 1985
Externally publishedYes

Fingerprint

Crystallins
Cataract
Lenses
Genes
Nucleic Acid Hybridization
Crystalline Lens
Southern Blotting
Northern Blotting
Cultured Cells
RNA
Messenger RNA
DNA

ASJC Scopus subject areas

  • General

Cite this

Garber, A. T., Winkler, C., Shinohara, T., King, C. R., Inana, G., Piatigorsky, J., & Gold, R. J. (1985). Selective loss of a family of gene transcripts in a hereditary murine cataract. Science, 227(4682), 74-77. https://doi.org/10.1126/science.3964960

Selective loss of a family of gene transcripts in a hereditary murine cataract. / Garber, A. T.; Winkler, C.; Shinohara, T.; King, C. R.; Inana, George; Piatigorsky, J.; Gold, R. J.

In: Science, Vol. 227, No. 4682, 27.03.1985, p. 74-77.

Research output: Contribution to journalArticle

Garber, AT, Winkler, C, Shinohara, T, King, CR, Inana, G, Piatigorsky, J & Gold, RJ 1985, 'Selective loss of a family of gene transcripts in a hereditary murine cataract', Science, vol. 227, no. 4682, pp. 74-77. https://doi.org/10.1126/science.3964960
Garber AT, Winkler C, Shinohara T, King CR, Inana G, Piatigorsky J et al. Selective loss of a family of gene transcripts in a hereditary murine cataract. Science. 1985 Mar 27;227(4682):74-77. https://doi.org/10.1126/science.3964960
Garber, A. T. ; Winkler, C. ; Shinohara, T. ; King, C. R. ; Inana, George ; Piatigorsky, J. ; Gold, R. J. / Selective loss of a family of gene transcripts in a hereditary murine cataract. In: Science. 1985 ; Vol. 227, No. 4682. pp. 74-77.
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