Selective loss of a family of gene transcripts in a hereditary marine cataract

A. T. Garber, C. Winkler, T. Shinohara, C. R. King, G. Inana, J. Piatigorsky, R. J.M. Gold

Research output: Contribution to journalArticlepeer-review

21 Scopus citations

Abstract

The eye lens of the Fraser mouse contains a dominantly inherited cataract with reduced amounts of seven distinct but homologous γ crystallins encoded by a family of γ-crystallin genes. The results of experiments with cultured lenses, cell-free RNA translation, and Northern blot hybridization indicated a specific loss of the family of γ-crystallin messenger RNA's in the Fraser mouse lens. Southern blot hybridization of genomic DNA's from normal and Fraser mice showed no differences in γ-crystallins coding sequences.

Original languageEnglish (US)
Pages (from-to)74-77
Number of pages4
JournalScience
Volume227
Issue number4682
DOIs
StatePublished - Jan 1 1985
Externally publishedYes

ASJC Scopus subject areas

  • General

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