Selective loss of a family of gene transcripts in a hereditary marine cataract

A. T. Garber, C. Winkler, T. Shinohara, C. R. King, G. Inana, J. Piatigorsky, R. J.M. Gold

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

The eye lens of the Fraser mouse contains a dominantly inherited cataract with reduced amounts of seven distinct but homologous γ crystallins encoded by a family of γ-crystallin genes. The results of experiments with cultured lenses, cell-free RNA translation, and Northern blot hybridization indicated a specific loss of the family of γ-crystallin messenger RNA's in the Fraser mouse lens. Southern blot hybridization of genomic DNA's from normal and Fraser mice showed no differences in γ-crystallins coding sequences.

Original languageEnglish (US)
Pages (from-to)74-77
Number of pages4
JournalScience
Volume227
Issue number4682
DOIs
StatePublished - Jan 1 1985
Externally publishedYes

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    Garber, A. T., Winkler, C., Shinohara, T., King, C. R., Inana, G., Piatigorsky, J., & Gold, R. J. M. (1985). Selective loss of a family of gene transcripts in a hereditary marine cataract. Science, 227(4682), 74-77. https://doi.org/10.1126/science.3964960