5 Bromodeoxycytidine and 5 iododeoxycytidine inhibited the replication of herpes simplex virus as effectively as did 5 bromodeoxyuridine and 5 iododeoxyuridine. However, the 5 halogenated analogues of deoxycytidine were 10 to 100 times less toxic to uninfected cells than the 5 halogenated analogues of deoxyuridine. The selective action of the halogenated analogues of deoxycytidine appears to be the result of a virus induced pyrimidine nucleoside kinase, which converts the halogenated analogues of deoxycytidine to halogenated analogues of deoxycytidylate. These results indicate that the 5 halogenated analogues of deoxycytidine are more selective inhibitors of herpes simplex virus replication than the 5 halogenated analogues of deoxyuridine.
|Original language||English (US)|
|Number of pages||6|
|State||Published - Dec 1 1975|
ASJC Scopus subject areas
- Molecular Medicine