Selective inhibition of the replication of herpes simplex virus by 5 halogenated analogues of deoxycytidine

I. Schildkraut, G. M. Cooper, S. Greer

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Abstract

5 Bromodeoxycytidine and 5 iododeoxycytidine inhibited the replication of herpes simplex virus as effectively as did 5 bromodeoxyuridine and 5 iododeoxyuridine. However, the 5 halogenated analogues of deoxycytidine were 10 to 100 times less toxic to uninfected cells than the 5 halogenated analogues of deoxyuridine. The selective action of the halogenated analogues of deoxycytidine appears to be the result of a virus induced pyrimidine nucleoside kinase, which converts the halogenated analogues of deoxycytidine to halogenated analogues of deoxycytidylate. These results indicate that the 5 halogenated analogues of deoxycytidine are more selective inhibitors of herpes simplex virus replication than the 5 halogenated analogues of deoxyuridine.

Original languageEnglish (US)
Pages (from-to)153-158
Number of pages6
JournalMolecular Pharmacology
Volume11
Issue number2
StatePublished - Dec 1 1975

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ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology

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