Abstract
To further characterize the receptor mediating histamine-induced impairment of atrioventricular conduction, the effects of two selective histamine H1-receptor agonists, 2-(2-pyridyl)-ethylamine (PEA) and 2-(2-thiazolyl)-ethylamine (ThEA), were investigated using the isolated guinea pig heart. These effects were compared with those of histamine and other selective agonists. PEA and ThEA produced a weak stimulation of cardiac rate and contractility; however, they produced a marked prolongation of atrioventricular conduction. The orders of relative potencies observed substantiate the hypothesis that H2-receptors mediate the positive inotropic and chronotropic effects and H1-receptors mediate the negative dromotropic effect of histamine.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 237-240 |
| Number of pages | 4 |
| Journal | European Journal of Pharmacology |
| Volume | 34 |
| Issue number | 1 |
| DOIs | |
| State | Published - Nov 1975 |
Keywords
- 2-(2-Pyridyl)-ethylamine
- 2-(2-Thiazolyl)-ethylamine
- Atrioventricular conduction
- Cardiac histamine receptors
ASJC Scopus subject areas
- Cellular and Molecular Neuroscience
- Pharmacology
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Levi, R., Ganellin, C. R., Allan, G., & Willens, H. J. (1975). Selective impairment of atrioventricular conduction by 2-(2-pyridyl)-ethylamine and 2-(2-thiazolyl)-ethylamine, two histamine H1-receptor agonists. European Journal of Pharmacology, 34(1), 237-240. https://doi.org/10.1016/0014-2999(75)90246-0