Selective impairment of atrioventricular conduction by 2-(2-pyridyl)-ethylamine and 2-(2-thiazolyl)-ethylamine, two histamine H1-receptor agonists

Roberto Levi, C. Robin Ganellin, Geoffrey Allan, Howard J. Willens

Research output: Contribution to journalArticle

25 Scopus citations


To further characterize the receptor mediating histamine-induced impairment of atrioventricular conduction, the effects of two selective histamine H1-receptor agonists, 2-(2-pyridyl)-ethylamine (PEA) and 2-(2-thiazolyl)-ethylamine (ThEA), were investigated using the isolated guinea pig heart. These effects were compared with those of histamine and other selective agonists. PEA and ThEA produced a weak stimulation of cardiac rate and contractility; however, they produced a marked prolongation of atrioventricular conduction. The orders of relative potencies observed substantiate the hypothesis that H2-receptors mediate the positive inotropic and chronotropic effects and H1-receptors mediate the negative dromotropic effect of histamine.

Original languageEnglish (US)
Pages (from-to)237-240
Number of pages4
JournalEuropean Journal of Pharmacology
Issue number1
StatePublished - Nov 1975



  • 2-(2-Pyridyl)-ethylamine
  • 2-(2-Thiazolyl)-ethylamine
  • Atrioventricular conduction
  • Cardiac histamine receptors

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

Cite this