Abstract
To further characterize the receptor mediating histamine-induced impairment of atrioventricular conduction, the effects of two selective histamine H1-receptor agonists, 2-(2-pyridyl)-ethylamine (PEA) and 2-(2-thiazolyl)-ethylamine (ThEA), were investigated using the isolated guinea pig heart. These effects were compared with those of histamine and other selective agonists. PEA and ThEA produced a weak stimulation of cardiac rate and contractility; however, they produced a marked prolongation of atrioventricular conduction. The orders of relative potencies observed substantiate the hypothesis that H2-receptors mediate the positive inotropic and chronotropic effects and H1-receptors mediate the negative dromotropic effect of histamine.
| Original language | English |
|---|---|
| Pages (from-to) | 237-240 |
| Number of pages | 4 |
| Journal | European Journal of Pharmacology |
| Volume | 34 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 1 1975 |
| Externally published | Yes |
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Keywords
- 2-(2-Pyridyl)-ethylamine
- 2-(2-Thiazolyl)-ethylamine
- Atrioventricular conduction
- Cardiac histamine receptors
ASJC Scopus subject areas
- Cellular and Molecular Neuroscience
- Pharmacology
Cite this
Selective impairment of atrioventricular conduction by 2-(2-pyridyl)-ethylamine and 2-(2-thiazolyl)-ethylamine, two histamine H1-receptor agonists. / Levi, Roberto; Ganellin, C. Robin; Allan, Geoffrey; Willens, Howard J.
In: European Journal of Pharmacology, Vol. 34, No. 1, 01.01.1975, p. 237-240.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Selective impairment of atrioventricular conduction by 2-(2-pyridyl)-ethylamine and 2-(2-thiazolyl)-ethylamine, two histamine H1-receptor agonists
AU - Levi, Roberto
AU - Ganellin, C. Robin
AU - Allan, Geoffrey
AU - Willens, Howard J.
PY - 1975/1/1
Y1 - 1975/1/1
N2 - To further characterize the receptor mediating histamine-induced impairment of atrioventricular conduction, the effects of two selective histamine H1-receptor agonists, 2-(2-pyridyl)-ethylamine (PEA) and 2-(2-thiazolyl)-ethylamine (ThEA), were investigated using the isolated guinea pig heart. These effects were compared with those of histamine and other selective agonists. PEA and ThEA produced a weak stimulation of cardiac rate and contractility; however, they produced a marked prolongation of atrioventricular conduction. The orders of relative potencies observed substantiate the hypothesis that H2-receptors mediate the positive inotropic and chronotropic effects and H1-receptors mediate the negative dromotropic effect of histamine.
AB - To further characterize the receptor mediating histamine-induced impairment of atrioventricular conduction, the effects of two selective histamine H1-receptor agonists, 2-(2-pyridyl)-ethylamine (PEA) and 2-(2-thiazolyl)-ethylamine (ThEA), were investigated using the isolated guinea pig heart. These effects were compared with those of histamine and other selective agonists. PEA and ThEA produced a weak stimulation of cardiac rate and contractility; however, they produced a marked prolongation of atrioventricular conduction. The orders of relative potencies observed substantiate the hypothesis that H2-receptors mediate the positive inotropic and chronotropic effects and H1-receptors mediate the negative dromotropic effect of histamine.
KW - 2-(2-Pyridyl)-ethylamine
KW - 2-(2-Thiazolyl)-ethylamine
KW - Atrioventricular conduction
KW - Cardiac histamine receptors
UR - http://www.scopus.com/inward/record.url?scp=0016816845&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0016816845&partnerID=8YFLogxK
U2 - 10.1016/0014-2999(75)90246-0
DO - 10.1016/0014-2999(75)90246-0
M3 - Article
C2 - 1234767
AN - SCOPUS:0016816845
VL - 34
SP - 237
EP - 240
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
SN - 0014-2999
IS - 1
ER -