Selective impairment of atrioventricular conduction by 2-(2-pyridyl)-ethylamine and 2-(2-thiazolyl)-ethylamine, two histamine H1-receptor agonists

Roberto Levi, C. Robin Ganellin, Geoffrey Allan, Howard J. Willens

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

To further characterize the receptor mediating histamine-induced impairment of atrioventricular conduction, the effects of two selective histamine H1-receptor agonists, 2-(2-pyridyl)-ethylamine (PEA) and 2-(2-thiazolyl)-ethylamine (ThEA), were investigated using the isolated guinea pig heart. These effects were compared with those of histamine and other selective agonists. PEA and ThEA produced a weak stimulation of cardiac rate and contractility; however, they produced a marked prolongation of atrioventricular conduction. The orders of relative potencies observed substantiate the hypothesis that H2-receptors mediate the positive inotropic and chronotropic effects and H1-receptors mediate the negative dromotropic effect of histamine.

Original languageEnglish
Pages (from-to)237-240
Number of pages4
JournalEuropean Journal of Pharmacology
Volume34
Issue number1
DOIs
StatePublished - Jan 1 1975
Externally publishedYes

Fingerprint

Histamine Agonists
Histamine
Histamine Receptors
Histamine H1 Receptors
Histamine H2 Receptors
Guinea Pigs
2-(2-aminoethyl)thiazole
2-(2-aminoethyl)pyridine

Keywords

  • 2-(2-Pyridyl)-ethylamine
  • 2-(2-Thiazolyl)-ethylamine
  • Atrioventricular conduction
  • Cardiac histamine receptors

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

Cite this

Selective impairment of atrioventricular conduction by 2-(2-pyridyl)-ethylamine and 2-(2-thiazolyl)-ethylamine, two histamine H1-receptor agonists. / Levi, Roberto; Ganellin, C. Robin; Allan, Geoffrey; Willens, Howard J.

In: European Journal of Pharmacology, Vol. 34, No. 1, 01.01.1975, p. 237-240.

Research output: Contribution to journalArticle

Levi, Roberto ; Ganellin, C. Robin ; Allan, Geoffrey ; Willens, Howard J. / Selective impairment of atrioventricular conduction by 2-(2-pyridyl)-ethylamine and 2-(2-thiazolyl)-ethylamine, two histamine H1-receptor agonists. In: European Journal of Pharmacology. 1975 ; Vol. 34, No. 1. pp. 237-240.
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