Selective defect in plasmacyoid dendritic cell function in a patient with AIDS-associated atypical genital herpes simplex vegetans treated with imiquimod.

Lillian Abbo; Vladimir Vincek; Gordon Dickinson; Niraj Shrestha; Susanne Doblecki; Patrick A.J. Haslett

doi:10.1086/510426

Selective defect in plasmacyoid dendritic cell function in a patient with AIDS-associated atypical genital herpes simplex vegetans treated with imiquimod.

Lillian Abbo, Vladimir Vincek, Gordon Dickinson, Niraj Shrestha, Susanne Doblecki, Patrick A.J. Haslett

Research output: Contribution to journal › Article › peer-review

37 Scopus citations

Abstract

We report a case of acquired immunodeficiency syndrome (AIDS)-associated, acyclovir-refractory genital herpes infection treated with topical imidazoquinoline therapy. The patient's plasmacytoid dendritic cells made a robust interferon- alpha response following in vitro stimulation with imidazoquinoline but not with herpes simplex virus. We hypothesize that disease resulting from defective herpes simplex virus-stimulated interferon- alpha may be overcome by stimulating intact alternative pathways.

Original language	English (US)
Pages (from-to)	e25-27
Journal	Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Volume	44
Issue number	3
DOIs	https://doi.org/10.1086/510426
State	Published - Feb 1 2007
Externally published	Yes

ASJC Scopus subject areas

Microbiology (medical)
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1086/510426

Cite this

Abbo, L., Vincek, V., Dickinson, G., Shrestha, N., Doblecki, S., & Haslett, P. A. J. (2007). Selective defect in plasmacyoid dendritic cell function in a patient with AIDS-associated atypical genital herpes simplex vegetans treated with imiquimod. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 44(3), e25-27. https://doi.org/10.1086/510426

Selective defect in plasmacyoid dendritic cell function in a patient with AIDS-associated atypical genital herpes simplex vegetans treated with imiquimod. / Abbo, Lillian; Vincek, Vladimir; Dickinson, Gordon; Shrestha, Niraj; Doblecki, Susanne; Haslett, Patrick A.J.

In: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, Vol. 44, No. 3, 01.02.2007, p. e25-27.

Research output: Contribution to journal › Article › peer-review

Abbo, L, Vincek, V, Dickinson, G, Shrestha, N, Doblecki, S & Haslett, PAJ 2007, 'Selective defect in plasmacyoid dendritic cell function in a patient with AIDS-associated atypical genital herpes simplex vegetans treated with imiquimod.', Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, vol. 44, no. 3, pp. e25-27. https://doi.org/10.1086/510426

Abbo L, Vincek V, Dickinson G, Shrestha N, Doblecki S, Haslett PAJ. Selective defect in plasmacyoid dendritic cell function in a patient with AIDS-associated atypical genital herpes simplex vegetans treated with imiquimod. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 2007 Feb 1;44(3):e25-27. https://doi.org/10.1086/510426

Abbo, Lillian ; Vincek, Vladimir ; Dickinson, Gordon ; Shrestha, Niraj ; Doblecki, Susanne ; Haslett, Patrick A.J. / Selective defect in plasmacyoid dendritic cell function in a patient with AIDS-associated atypical genital herpes simplex vegetans treated with imiquimod. In: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 2007 ; Vol. 44, No. 3. pp. e25-27.

@article{7232a19d5c054c05901f77e8af459fb3,

title = "Selective defect in plasmacyoid dendritic cell function in a patient with AIDS-associated atypical genital herpes simplex vegetans treated with imiquimod.",

abstract = "We report a case of acquired immunodeficiency syndrome (AIDS)-associated, acyclovir-refractory genital herpes infection treated with topical imidazoquinoline therapy. The patient's plasmacytoid dendritic cells made a robust interferon- alpha response following in vitro stimulation with imidazoquinoline but not with herpes simplex virus. We hypothesize that disease resulting from defective herpes simplex virus-stimulated interferon- alpha may be overcome by stimulating intact alternative pathways.",

author = "Lillian Abbo and Vladimir Vincek and Gordon Dickinson and Niraj Shrestha and Susanne Doblecki and Haslett, {Patrick A.J.}",

note = "Funding Information: We thank 3M Pharmaceuticals for kindly providing resiquimod. Financial support. Dana Foundation Human Immunology Program grant (to P.A.J.H.). Potential conflicts of interest. All authors: no conflicts.",

year = "2007",

month = feb,

day = "1",

doi = "10.1086/510426",

language = "English (US)",

volume = "44",

pages = "e25--27",

journal = "Clinical Infectious Diseases",

issn = "1058-4838",

publisher = "Oxford University Press",

number = "3",

}

TY - JOUR

T1 - Selective defect in plasmacyoid dendritic cell function in a patient with AIDS-associated atypical genital herpes simplex vegetans treated with imiquimod.

AU - Abbo, Lillian

AU - Vincek, Vladimir

AU - Dickinson, Gordon

AU - Shrestha, Niraj

AU - Doblecki, Susanne

AU - Haslett, Patrick A.J.

N1 - Funding Information: We thank 3M Pharmaceuticals for kindly providing resiquimod. Financial support. Dana Foundation Human Immunology Program grant (to P.A.J.H.). Potential conflicts of interest. All authors: no conflicts.

PY - 2007/2/1

Y1 - 2007/2/1

N2 - We report a case of acquired immunodeficiency syndrome (AIDS)-associated, acyclovir-refractory genital herpes infection treated with topical imidazoquinoline therapy. The patient's plasmacytoid dendritic cells made a robust interferon- alpha response following in vitro stimulation with imidazoquinoline but not with herpes simplex virus. We hypothesize that disease resulting from defective herpes simplex virus-stimulated interferon- alpha may be overcome by stimulating intact alternative pathways.

AB - We report a case of acquired immunodeficiency syndrome (AIDS)-associated, acyclovir-refractory genital herpes infection treated with topical imidazoquinoline therapy. The patient's plasmacytoid dendritic cells made a robust interferon- alpha response following in vitro stimulation with imidazoquinoline but not with herpes simplex virus. We hypothesize that disease resulting from defective herpes simplex virus-stimulated interferon- alpha may be overcome by stimulating intact alternative pathways.

UR - http://www.scopus.com/inward/record.url?scp=33846927030&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33846927030&partnerID=8YFLogxK

U2 - 10.1086/510426

DO - 10.1086/510426

M3 - Article

C2 - 17205432

AN - SCOPUS:33846927030

VL - 44

SP - e25-27

JO - Clinical Infectious Diseases

JF - Clinical Infectious Diseases

SN - 1058-4838

IS - 3

ER -

Selective defect in plasmacyoid dendritic cell function in a patient with AIDS-associated atypical genital herpes simplex vegetans treated with imiquimod.

Abstract

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this