Abstract
We report a case of acquired immunodeficiency syndrome (AIDS)-associated, acyclovir-refractory genital herpes infection treated with topical imidazoquinoline therapy. The patient's plasmacytoid dendritic cells made a robust interferon- alpha response following in vitro stimulation with imidazoquinoline but not with herpes simplex virus. We hypothesize that disease resulting from defective herpes simplex virus-stimulated interferon- alpha may be overcome by stimulating intact alternative pathways.
Original language | English (US) |
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Pages (from-to) | e25-27 |
Journal | Clinical infectious diseases : an official publication of the Infectious Diseases Society of America |
Volume | 44 |
Issue number | 3 |
DOIs | |
State | Published - Feb 1 2007 |
ASJC Scopus subject areas
- Microbiology (medical)
- Infectious Diseases