Selective defect in plasmacyoid dendritic cell function in a patient with AIDS-associated atypical genital herpes simplex vegetans treated with imiquimod.

Lilian Abbo, Vladimir Vincek, Gordon Dickinson, Niraj Shrestha, Susanne Doblecki-Lewis, Patrick A J Haslett

Research output: Contribution to journal › Article

35 Citations (Scopus)

Abstract

We report a case of acquired immunodeficiency syndrome (AIDS)-associated, acyclovir-refractory genital herpes infection treated with topical imidazoquinoline therapy. The patient's plasmacytoid dendritic cells made a robust interferon- alpha response following in vitro stimulation with imidazoquinoline but not with herpes simplex virus. We hypothesize that disease resulting from defective herpes simplex virus-stimulated interferon- alpha may be overcome by stimulating intact alternative pathways.

Original languageEnglish
JournalClinical infectious diseases : an official publication of the Infectious Diseases Society of America
Volume44
Issue number3
DOIs
StatePublished - Feb 1 2007
Externally publishedYes

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imiquimod
Herpes Genitalis
Simplexvirus
Interferon-alpha
Dendritic Cells
Acquired Immunodeficiency Syndrome
Defective Viruses
Acyclovir
Infection
vegetan
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

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Selective defect in plasmacyoid dendritic cell function in a patient with AIDS-associated atypical genital herpes simplex vegetans treated with imiquimod. / Abbo, Lilian; Vincek, Vladimir; Dickinson, Gordon; Shrestha, Niraj; Doblecki-Lewis, Susanne; Haslett, Patrick A J.

In: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, Vol. 44, No. 3, 01.02.2007.

Research output: Contribution to journal › Article

Abbo, L, Vincek, V, Dickinson, G, Shrestha, N, Doblecki-Lewis, S & Haslett, PAJ 2007, 'Selective defect in plasmacyoid dendritic cell function in a patient with AIDS-associated atypical genital herpes simplex vegetans treated with imiquimod.', Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, vol. 44, no. 3. https://doi.org/10.1086/510426
Abbo L, Vincek V, Dickinson G, Shrestha N, Doblecki-Lewis S, Haslett PAJ. Selective defect in plasmacyoid dendritic cell function in a patient with AIDS-associated atypical genital herpes simplex vegetans treated with imiquimod. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 2007 Feb 1;44(3). https://doi.org/10.1086/510426
Abbo, Lilian ; Vincek, Vladimir ; Dickinson, Gordon ; Shrestha, Niraj ; Doblecki-Lewis, Susanne ; Haslett, Patrick A J. / Selective defect in plasmacyoid dendritic cell function in a patient with AIDS-associated atypical genital herpes simplex vegetans treated with imiquimod. In: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 2007 ; Vol. 44, No. 3.
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