Selective defect in plasmacyoid dendritic cell function in a patient with AIDS-associated atypical genital herpes simplex vegetans treated with imiquimod.

Lillian Abbo; Vladimir Vincek; Gordon Dickinson; Niraj Shrestha; Susanne Doblecki; Patrick A.J. Haslett

doi:10.1086/510426

Selective defect in plasmacyoid dendritic cell function in a patient with AIDS-associated atypical genital herpes simplex vegetans treated with imiquimod.

Lillian Abbo, Vladimir Vincek, Gordon Dickinson, Niraj Shrestha, Susanne Doblecki, Patrick A.J. Haslett

Medicine

Research output: Contribution to journal › Article › peer-review

36 Scopus citations

Abstract

We report a case of acquired immunodeficiency syndrome (AIDS)-associated, acyclovir-refractory genital herpes infection treated with topical imidazoquinoline therapy. The patient's plasmacytoid dendritic cells made a robust interferon- alpha response following in vitro stimulation with imidazoquinoline but not with herpes simplex virus. We hypothesize that disease resulting from defective herpes simplex virus-stimulated interferon- alpha may be overcome by stimulating intact alternative pathways.

Original language	English (US)
Pages (from-to)	e25-27
Journal	Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Volume	44
Issue number	3
DOIs	https://doi.org/10.1086/510426
State	Published - Feb 1 2007

ASJC Scopus subject areas

Microbiology (medical)
Infectious Diseases

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10.1086/510426

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Abbo, L., Vincek, V., Dickinson, G., Shrestha, N., Doblecki, S., & Haslett, P. A. J. (2007). Selective defect in plasmacyoid dendritic cell function in a patient with AIDS-associated atypical genital herpes simplex vegetans treated with imiquimod. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 44(3), e25-27. https://doi.org/10.1086/510426

Selective defect in plasmacyoid dendritic cell function in a patient with AIDS-associated atypical genital herpes simplex vegetans treated with imiquimod. / Abbo, Lillian; Vincek, Vladimir; Dickinson, Gordon; Shrestha, Niraj; Doblecki, Susanne; Haslett, Patrick A.J.

In: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, Vol. 44, No. 3, 01.02.2007, p. e25-27.

Research output: Contribution to journal › Article › peer-review

Abbo, L, Vincek, V, Dickinson, G, Shrestha, N, Doblecki, S & Haslett, PAJ 2007, 'Selective defect in plasmacyoid dendritic cell function in a patient with AIDS-associated atypical genital herpes simplex vegetans treated with imiquimod.', Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, vol. 44, no. 3, pp. e25-27. https://doi.org/10.1086/510426

Abbo L, Vincek V, Dickinson G, Shrestha N, Doblecki S, Haslett PAJ. Selective defect in plasmacyoid dendritic cell function in a patient with AIDS-associated atypical genital herpes simplex vegetans treated with imiquimod. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 2007 Feb 1;44(3):e25-27. https://doi.org/10.1086/510426

Abbo, Lillian ; Vincek, Vladimir ; Dickinson, Gordon ; Shrestha, Niraj ; Doblecki, Susanne ; Haslett, Patrick A.J. / Selective defect in plasmacyoid dendritic cell function in a patient with AIDS-associated atypical genital herpes simplex vegetans treated with imiquimod. In: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 2007 ; Vol. 44, No. 3. pp. e25-27.

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abstract = "We report a case of acquired immunodeficiency syndrome (AIDS)-associated, acyclovir-refractory genital herpes infection treated with topical imidazoquinoline therapy. The patient's plasmacytoid dendritic cells made a robust interferon- alpha response following in vitro stimulation with imidazoquinoline but not with herpes simplex virus. We hypothesize that disease resulting from defective herpes simplex virus-stimulated interferon- alpha may be overcome by stimulating intact alternative pathways.",

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note = "Funding Information: We thank 3M Pharmaceuticals for kindly providing resiquimod. Financial support. Dana Foundation Human Immunology Program grant (to P.A.J.H.). Potential conflicts of interest. All authors: no conflicts.",

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