Selective defect in plasmacyoid dendritic cell function in a patient with AIDS-associated atypical genital herpes simplex vegetans treated with imiquimod.

Lilian Abbo, Vladimir Vincek, Gordon Dickinson, Niraj Shrestha, Susanne Doblecki-Lewis, Patrick A J Haslett

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

We report a case of acquired immunodeficiency syndrome (AIDS)-associated, acyclovir-refractory genital herpes infection treated with topical imidazoquinoline therapy. The patient's plasmacytoid dendritic cells made a robust interferon- alpha response following in vitro stimulation with imidazoquinoline but not with herpes simplex virus. We hypothesize that disease resulting from defective herpes simplex virus-stimulated interferon- alpha may be overcome by stimulating intact alternative pathways.

Original languageEnglish
JournalClinical infectious diseases : an official publication of the Infectious Diseases Society of America
Volume44
Issue number3
DOIs
StatePublished - Feb 1 2007
Externally publishedYes

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imiquimod
Herpes Genitalis
Simplexvirus
Interferon-alpha
Dendritic Cells
Acquired Immunodeficiency Syndrome
Defective Viruses
Acyclovir
Infection
vegetan
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

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