Selective cooperation of HTLV-1-encoded p40(tax-1) with cellular oncoproteins in the induction of hematopoietic cell proliferation

T. Miyazaki, Z. J. Liu, T. Taniguchi

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

Human T cell leukemia virus type 1 (HTLV-1) is the etiologic agent of adult T cell leukemia (ATL). The virus-encoded p40(tax-1), a nuclear oncoprotein, is known to promote transcription of its own as well as a variety of cellular genes. However, the mechanism by which p40(tax-1) promotes lymphocyte transformation is not fully understood. In the present study, we examined whether p40(tax-1) can induce hematopoietic cell proliferation by cooperating with the products of cellular proto-oncogenes; i.e. an activated form of the src-family protein tyrosine kinase p56(lck) (lck F505), c-Myc or Bcl-2. These oncoproteins are critical mediators of interleukin 2 (IL-2)-induced proliferative signals. We show that p40(tax-1) alone cannot render the hematopoietic cell line, BAF-B03, able to proliferate in the absence of cytokines, but it can do so in cooperation with lckF505, or c-Myc but not with Bcl-2.

Original languageEnglish (US)
Pages (from-to)2403-2408
Number of pages6
JournalOncogene
Volume12
Issue number11
StatePublished - Jul 5 1996
Externally publishedYes

Keywords

  • Bcl-2
  • c-Myc
  • HTLV-1
  • IL-2
  • lck F505
  • p40(tax-1)

ASJC Scopus subject areas

  • Molecular Biology
  • Cancer Research
  • Genetics

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