Abstract
Human T cell leukemia virus type 1 (HTLV-1) is the etiologic agent of adult T cell leukemia (ATL). The virus-encoded p40(tax-1), a nuclear oncoprotein, is known to promote transcription of its own as well as a variety of cellular genes. However, the mechanism by which p40(tax-1) promotes lymphocyte transformation is not fully understood. In the present study, we examined whether p40(tax-1) can induce hematopoietic cell proliferation by cooperating with the products of cellular proto-oncogenes; i.e. an activated form of the src-family protein tyrosine kinase p56(lck) (lck F505), c-Myc or Bcl-2. These oncoproteins are critical mediators of interleukin 2 (IL-2)-induced proliferative signals. We show that p40(tax-1) alone cannot render the hematopoietic cell line, BAF-B03, able to proliferate in the absence of cytokines, but it can do so in cooperation with lckF505, or c-Myc but not with Bcl-2.
Original language | English (US) |
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Pages (from-to) | 2403-2408 |
Number of pages | 6 |
Journal | Oncogene |
Volume | 12 |
Issue number | 11 |
State | Published - 1996 |
Externally published | Yes |
Keywords
- Bcl-2
- c-Myc
- HTLV-1
- IL-2
- lck F505
- p40(tax-1)
ASJC Scopus subject areas
- Molecular Biology
- Cancer Research
- Genetics