Abstract
Human T cell leukemia virus type 1 (HTLV-1) is the etiologic agent of adult T cell leukemia (ATL). The virus-encoded p40(tax-1), a nuclear oncoprotein, is known to promote transcription of its own as well as a variety of cellular genes. However, the mechanism by which p40(tax-1) promotes lymphocyte transformation is not fully understood. In the present study, we examined whether p40(tax-1) can induce hematopoietic cell proliferation by cooperating with the products of cellular proto-oncogenes; i.e. an activated form of the src-family protein tyrosine kinase p56(lck) (lck F505), c-Myc or Bcl-2. These oncoproteins are critical mediators of interleukin 2 (IL-2)-induced proliferative signals. We show that p40(tax-1) alone cannot render the hematopoietic cell line, BAF-B03, able to proliferate in the absence of cytokines, but it can do so in cooperation with lckF505, or c-Myc but not with Bcl-2.
| Original language | English |
|---|---|
| Pages (from-to) | 2403-2408 |
| Number of pages | 6 |
| Journal | Oncogene |
| Volume | 12 |
| Issue number | 11 |
| State | Published - Jul 5 1996 |
| Externally published | Yes |
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Keywords
- Bcl-2
- c-Myc
- HTLV-1
- IL-2
- lck F505
- p40(tax-1)
ASJC Scopus subject areas
- Molecular Biology
- Cancer Research
- Genetics
Cite this
Selective cooperation of HTLV-1-encoded p40(tax-1) with cellular oncoproteins in the induction of hematopoietic cell proliferation. / Miyazaki, T.; Liu, Zhao-Jun; Taniguchi, T.
In: Oncogene, Vol. 12, No. 11, 05.07.1996, p. 2403-2408.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Selective cooperation of HTLV-1-encoded p40(tax-1) with cellular oncoproteins in the induction of hematopoietic cell proliferation
AU - Miyazaki, T.
AU - Liu, Zhao-Jun
AU - Taniguchi, T.
PY - 1996/7/5
Y1 - 1996/7/5
N2 - Human T cell leukemia virus type 1 (HTLV-1) is the etiologic agent of adult T cell leukemia (ATL). The virus-encoded p40(tax-1), a nuclear oncoprotein, is known to promote transcription of its own as well as a variety of cellular genes. However, the mechanism by which p40(tax-1) promotes lymphocyte transformation is not fully understood. In the present study, we examined whether p40(tax-1) can induce hematopoietic cell proliferation by cooperating with the products of cellular proto-oncogenes; i.e. an activated form of the src-family protein tyrosine kinase p56(lck) (lck F505), c-Myc or Bcl-2. These oncoproteins are critical mediators of interleukin 2 (IL-2)-induced proliferative signals. We show that p40(tax-1) alone cannot render the hematopoietic cell line, BAF-B03, able to proliferate in the absence of cytokines, but it can do so in cooperation with lckF505, or c-Myc but not with Bcl-2.
AB - Human T cell leukemia virus type 1 (HTLV-1) is the etiologic agent of adult T cell leukemia (ATL). The virus-encoded p40(tax-1), a nuclear oncoprotein, is known to promote transcription of its own as well as a variety of cellular genes. However, the mechanism by which p40(tax-1) promotes lymphocyte transformation is not fully understood. In the present study, we examined whether p40(tax-1) can induce hematopoietic cell proliferation by cooperating with the products of cellular proto-oncogenes; i.e. an activated form of the src-family protein tyrosine kinase p56(lck) (lck F505), c-Myc or Bcl-2. These oncoproteins are critical mediators of interleukin 2 (IL-2)-induced proliferative signals. We show that p40(tax-1) alone cannot render the hematopoietic cell line, BAF-B03, able to proliferate in the absence of cytokines, but it can do so in cooperation with lckF505, or c-Myc but not with Bcl-2.
KW - Bcl-2
KW - c-Myc
KW - HTLV-1
KW - IL-2
KW - lck F505
KW - p40(tax-1)
UR - http://www.scopus.com/inward/record.url?scp=0029944223&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0029944223&partnerID=8YFLogxK
M3 - Article
VL - 12
SP - 2403
EP - 2408
JO - Oncogene
JF - Oncogene
SN - 0950-9232
IS - 11
ER -