Selective changes in μ, δ and ϰ opioid receptor binding in certain limbic regions of the brain in Alzheimer's disease patients

Jacob M. Hiller, Yossef Itzhak, Eric J. Simon

Research output: Contribution to journalArticlepeer-review

78 Scopus citations

Abstract

Total opioid binding and levels of the three major types of opioid binding sites were measured in homogenates of various limbic structures from post-mortem brains of Alzheimer's disease patients and age-matched control individuals. The most consistent finding in Alzheimer's disease brains was an increase in κ{script} binding in all 6 areas of the limbic system examined, with the putamen and caudate regions showing significant increases of 114% and 53%, respectively. In addition, the Alzheimer's disease putamen showed a significantly higher level of total binding (85% increase). The amygdala of Alzheimer's disease patients exhibited significantly lower levels of μ and δ binding (41% and 55% decrease, respectively). Total binding and binding to μ and δ receptors in frontal cortex, caudate and hippocampus of Alzheimer's disease brains was indistinguishable from levels seen in these brain areas from control individuals.

Original languageEnglish (US)
Pages (from-to)17-23
Number of pages7
JournalBrain research
Volume406
Issue number1-2
DOIs
StatePublished - Mar 17 1987

Keywords

  • Alzheimer's disease
  • Human brain
  • Multiple opioid receptor
  • Radioreceptor assay

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

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