Selective brain cooling with endovascular intracarotid infusion of cold saline: A pilot feasibility study

Jae H. Choi, R. S. Marshall, M. A. Neimark, A. A. Konstas, E. Lin, Y. T. Chiang, H. Mast, Tatjana Rundek, J. P. Mohr, J. Pile-Spellman

Research output: Contribution to journalArticle

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Abstract

BACKGROUND AND PURPOSE: Endovascular brain cooling as a method for rapid and selective induction of hypothermic neuroprotection has not been systematically studied in humans. In this clinical pilot study we investigated the feasibility, safety, and physiologic responses of short-term brain cooling with IC-CSI. MATERIALS AND METHODS: We studied 18 patients (50 ± 10 years old, 9 women) undergoing follow-up cerebral angiography after previous treatment of vascular malformations. Isotonic saline (4-17°C) was infused into 1 internal carotid artery at 33 mL/min for 10 minutes. Brain (JVB) and bladder/esophageal temperature measurements (n = 9) were performed. Both MCAs were monitored with transcranial Doppler sonography (n = 13). Arterial and JV blood were sampled to estimate hemodilution and brain oxygen extraction. RESULTS: JVB temperature dropped ∼0.84 ± 0.13°C and systemic temperature by 0.15 ± 0.08° C from baseline (JVB versus systemic temperature: P = .0006). Systolic MCA-flow velocities decreased from 101 ± 27 to 73 ± 18 cm/s on the infused side and from 83 ± 24 to 78 ± 21 cm/s on the contralateral side (relative changes, -26 ± 8% versus -4 ± 27%; P = .009). Changes in hematocrit (-1.2 ± 1.1%) and cerebral arteriovenous oxygen difference (0.2 ± 1.0 mL O 2/100 mL) were not significant. Doppler data showed no signs of vascular spasm or microemboli. No focal neurologic deficits occurred. Pain was not reported. CONCLUSIONS: The results of this pilot study suggest that brain cooling can be achieved safely, rapidly, and selectively by means of IC-CSI, opening a new potential avenue for acute neuroprotection. Clinical investigations with control of infusion parameters and measurements of CBF, oxygen consumption, and brain temperature are warranted.

Original languageEnglish
Pages (from-to)928-934
Number of pages7
JournalAmerican Journal of Neuroradiology
Volume31
Issue number5
DOIs
StatePublished - May 1 2010
Externally publishedYes

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Feasibility Studies
Brain
Temperature
Oxygen
Doppler Transcranial Ultrasonography
Cerebral Angiography
Hemodilution
Vascular Malformations
Spasm
Internal Carotid Artery
Neurologic Manifestations
Hematocrit
Oxygen Consumption
Blood Vessels
Urinary Bladder
Safety
Pain

ASJC Scopus subject areas

  • Clinical Neurology
  • Radiology Nuclear Medicine and imaging

Cite this

Choi, J. H., Marshall, R. S., Neimark, M. A., Konstas, A. A., Lin, E., Chiang, Y. T., ... Pile-Spellman, J. (2010). Selective brain cooling with endovascular intracarotid infusion of cold saline: A pilot feasibility study. American Journal of Neuroradiology, 31(5), 928-934. https://doi.org/10.3174/ajnr.A1961

Selective brain cooling with endovascular intracarotid infusion of cold saline : A pilot feasibility study. / Choi, Jae H.; Marshall, R. S.; Neimark, M. A.; Konstas, A. A.; Lin, E.; Chiang, Y. T.; Mast, H.; Rundek, Tatjana; Mohr, J. P.; Pile-Spellman, J.

In: American Journal of Neuroradiology, Vol. 31, No. 5, 01.05.2010, p. 928-934.

Research output: Contribution to journalArticle

Choi, JH, Marshall, RS, Neimark, MA, Konstas, AA, Lin, E, Chiang, YT, Mast, H, Rundek, T, Mohr, JP & Pile-Spellman, J 2010, 'Selective brain cooling with endovascular intracarotid infusion of cold saline: A pilot feasibility study', American Journal of Neuroradiology, vol. 31, no. 5, pp. 928-934. https://doi.org/10.3174/ajnr.A1961
Choi, Jae H. ; Marshall, R. S. ; Neimark, M. A. ; Konstas, A. A. ; Lin, E. ; Chiang, Y. T. ; Mast, H. ; Rundek, Tatjana ; Mohr, J. P. ; Pile-Spellman, J. / Selective brain cooling with endovascular intracarotid infusion of cold saline : A pilot feasibility study. In: American Journal of Neuroradiology. 2010 ; Vol. 31, No. 5. pp. 928-934.
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AU - Konstas, A. A.

AU - Lin, E.

AU - Chiang, Y. T.

AU - Mast, H.

AU - Rundek, Tatjana

AU - Mohr, J. P.

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