To evaluate the effect of selective brain cooling on cortical cerebral blood flow, we reduced brain temperature in nitrous oxide anesthetized adult rats using a high speed fan while keeping rectal temperature at 37-38°C. During selective brain cooling, cortical cerebral blood flow, as measured by laser-Doppler flowmetry, increased to 215 ± 26% (mean ± SE) of baseline at a cortical brain temperature of 30.9 ± 0.5°C and a rectal temperature of 37.5 ± 0.1°C. During rewarming, as brain temperature increased, cortical cerebral blood flow decreased. The cerebral vasodilatory response to hypothermia may explain its protective effects during and after cerebral ischemia.
|Original language||English (US)|
|Journal||American Journal of Physiology - Heart and Circulatory Physiology|
|Issue number||3 34-3|
|State||Published - 1993|
- cerebral vascular resistance
- laser-Doppler flowmetry
ASJC Scopus subject areas