Selective brain cooling increases cortical cerebral blood flow in rats

J. W. Kuluz, R. Prado, J. Chang, M. D. Ginsberg, C. L. Schleien, R. Busto

Research output: Contribution to journalArticlepeer-review

70 Scopus citations


To evaluate the effect of selective brain cooling on cortical cerebral blood flow, we reduced brain temperature in nitrous oxide anesthetized adult rats using a high speed fan while keeping rectal temperature at 37-38°C. During selective brain cooling, cortical cerebral blood flow, as measured by laser-Doppler flowmetry, increased to 215 ± 26% (mean ± SE) of baseline at a cortical brain temperature of 30.9 ± 0.5°C and a rectal temperature of 37.5 ± 0.1°C. During rewarming, as brain temperature increased, cortical cerebral blood flow decreased. The cerebral vasodilatory response to hypothermia may explain its protective effects during and after cerebral ischemia.

Original languageEnglish (US)
Pages (from-to)H824-H827
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Issue number3 34-3
StatePublished - 1993


  • cerebral vascular resistance
  • hypothermia
  • laser-Doppler flowmetry
  • temperature

ASJC Scopus subject areas

  • Physiology


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