Selective brain cooling increases cortical cerebral blood flow in rats

J. W. Kuluz, R. Prado, J. Chang, Myron Ginsberg, C. L. Schleien, R. Busto

Research output: Contribution to journalArticle

69 Citations (Scopus)

Abstract

To evaluate the effect of selective brain cooling on cortical cerebral blood flow, we reduced brain temperature in nitrous oxide anesthetized adult rats using a high speed fan while keeping rectal temperature at 37-38°C. During selective brain cooling, cortical cerebral blood flow, as measured by laser-Doppler flowmetry, increased to 215 ± 26% (mean ± SE) of baseline at a cortical brain temperature of 30.9 ± 0.5°C and a rectal temperature of 37.5 ± 0.1°C. During rewarming, as brain temperature increased, cortical cerebral blood flow decreased. The cerebral vasodilatory response to hypothermia may explain its protective effects during and after cerebral ischemia.

Original languageEnglish
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Volume265
Issue number3 34-3
StatePublished - Jan 1 1993

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Cerebrovascular Circulation
Temperature
Brain
Rewarming
Laser-Doppler Flowmetry
Nitrous Oxide
Hypothermia
Brain Ischemia

Keywords

  • cerebral vascular resistance
  • hypothermia
  • laser-Doppler flowmetry
  • temperature

ASJC Scopus subject areas

  • Physiology

Cite this

Selective brain cooling increases cortical cerebral blood flow in rats. / Kuluz, J. W.; Prado, R.; Chang, J.; Ginsberg, Myron; Schleien, C. L.; Busto, R.

In: American Journal of Physiology - Heart and Circulatory Physiology, Vol. 265, No. 3 34-3, 01.01.1993.

Research output: Contribution to journalArticle

Kuluz, J. W. ; Prado, R. ; Chang, J. ; Ginsberg, Myron ; Schleien, C. L. ; Busto, R. / Selective brain cooling increases cortical cerebral blood flow in rats. In: American Journal of Physiology - Heart and Circulatory Physiology. 1993 ; Vol. 265, No. 3 34-3.
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