Selective autonomic blockades. Effects upon classical conditioning of heart rate and lever lift suppression in rabbits

L. D. Sampson, J. Francis, Neil Schneiderman

Research output: Chapter in Book/Report/Conference proceedingChapter

8 Scopus citations

Abstract

Heart rate, blood pressure and lever lifting were studied during differential classical conditioning. The unconditioned stimulus was electrical stimulation of the septal region or the hypothalamus through chronically implanted electrodes; the conditioned stimuli were 2 tones differing in frequency. Beta adrenergic blockade by propranolol did not affect cardiovascular unconditioned responses (URs, bradycardia and pressor response), conditioned responses (CRs, bradycardia), or lever lift responses, whereas cholinergic blockade by atropine methylnitrate abolished heart rate responses but not lever lift responses. This indicates that heart rate responses were mediated by increases in vagal tone. Alpha adrenergic blockade by phentolamine abolished bradycardia and pressor URs, but not bradycardia CRs. This suggests that separate central mechanisms mediated bradycardia URs and CRs. Removal of the lever diminished without eliminating bradycardia CRs, indicating partial independence between lever lift and cardiac CRs.

Original languageEnglish
Title of host publicationJournal of Comparative and Physiological Psychology
Pages953-962
Number of pages10
Volume87
Edition5
StatePublished - Dec 1 1974
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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