Selective autonomic blockades. Effects upon classical conditioning of heart rate and lever lift suppression in rabbits

L. D. Sampson, J. Francis, Neil Schneiderman

Research output: Chapter in Book/Report/Conference proceedingChapter

8 Citations (Scopus)

Abstract

Heart rate, blood pressure and lever lifting were studied during differential classical conditioning. The unconditioned stimulus was electrical stimulation of the septal region or the hypothalamus through chronically implanted electrodes; the conditioned stimuli were 2 tones differing in frequency. Beta adrenergic blockade by propranolol did not affect cardiovascular unconditioned responses (URs, bradycardia and pressor response), conditioned responses (CRs, bradycardia), or lever lift responses, whereas cholinergic blockade by atropine methylnitrate abolished heart rate responses but not lever lift responses. This indicates that heart rate responses were mediated by increases in vagal tone. Alpha adrenergic blockade by phentolamine abolished bradycardia and pressor URs, but not bradycardia CRs. This suggests that separate central mechanisms mediated bradycardia URs and CRs. Removal of the lever diminished without eliminating bradycardia CRs, indicating partial independence between lever lift and cardiac CRs.

Original languageEnglish
Title of host publicationJournal of Comparative and Physiological Psychology
Pages953-962
Number of pages10
Volume87
Edition5
StatePublished - Dec 1 1974
Externally publishedYes

Fingerprint

Classical Conditioning
Bradycardia
Heart Rate
Rabbits
Adrenergic Agents
Septum of Brain
Implanted Electrodes
Phentolamine
Atropine
Propranolol
Cholinergic Agents
Electric Stimulation
Hypothalamus
Blood Pressure

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Sampson, L. D., Francis, J., & Schneiderman, N. (1974). Selective autonomic blockades. Effects upon classical conditioning of heart rate and lever lift suppression in rabbits. In Journal of Comparative and Physiological Psychology (5 ed., Vol. 87, pp. 953-962)

Selective autonomic blockades. Effects upon classical conditioning of heart rate and lever lift suppression in rabbits. / Sampson, L. D.; Francis, J.; Schneiderman, Neil.

Journal of Comparative and Physiological Psychology. Vol. 87 5. ed. 1974. p. 953-962.

Research output: Chapter in Book/Report/Conference proceedingChapter

Sampson, LD, Francis, J & Schneiderman, N 1974, Selective autonomic blockades. Effects upon classical conditioning of heart rate and lever lift suppression in rabbits. in Journal of Comparative and Physiological Psychology. 5 edn, vol. 87, pp. 953-962.
Sampson LD, Francis J, Schneiderman N. Selective autonomic blockades. Effects upon classical conditioning of heart rate and lever lift suppression in rabbits. In Journal of Comparative and Physiological Psychology. 5 ed. Vol. 87. 1974. p. 953-962
Sampson, L. D. ; Francis, J. ; Schneiderman, Neil. / Selective autonomic blockades. Effects upon classical conditioning of heart rate and lever lift suppression in rabbits. Journal of Comparative and Physiological Psychology. Vol. 87 5. ed. 1974. pp. 953-962
@inbook{788e072c9c3945cfadd88c04eab75f88,
title = "Selective autonomic blockades. Effects upon classical conditioning of heart rate and lever lift suppression in rabbits",
abstract = "Heart rate, blood pressure and lever lifting were studied during differential classical conditioning. The unconditioned stimulus was electrical stimulation of the septal region or the hypothalamus through chronically implanted electrodes; the conditioned stimuli were 2 tones differing in frequency. Beta adrenergic blockade by propranolol did not affect cardiovascular unconditioned responses (URs, bradycardia and pressor response), conditioned responses (CRs, bradycardia), or lever lift responses, whereas cholinergic blockade by atropine methylnitrate abolished heart rate responses but not lever lift responses. This indicates that heart rate responses were mediated by increases in vagal tone. Alpha adrenergic blockade by phentolamine abolished bradycardia and pressor URs, but not bradycardia CRs. This suggests that separate central mechanisms mediated bradycardia URs and CRs. Removal of the lever diminished without eliminating bradycardia CRs, indicating partial independence between lever lift and cardiac CRs.",
author = "Sampson, {L. D.} and J. Francis and Neil Schneiderman",
year = "1974",
month = "12",
day = "1",
language = "English",
volume = "87",
pages = "953--962",
booktitle = "Journal of Comparative and Physiological Psychology",
edition = "5",

}

TY - CHAP

T1 - Selective autonomic blockades. Effects upon classical conditioning of heart rate and lever lift suppression in rabbits

AU - Sampson, L. D.

AU - Francis, J.

AU - Schneiderman, Neil

PY - 1974/12/1

Y1 - 1974/12/1

N2 - Heart rate, blood pressure and lever lifting were studied during differential classical conditioning. The unconditioned stimulus was electrical stimulation of the septal region or the hypothalamus through chronically implanted electrodes; the conditioned stimuli were 2 tones differing in frequency. Beta adrenergic blockade by propranolol did not affect cardiovascular unconditioned responses (URs, bradycardia and pressor response), conditioned responses (CRs, bradycardia), or lever lift responses, whereas cholinergic blockade by atropine methylnitrate abolished heart rate responses but not lever lift responses. This indicates that heart rate responses were mediated by increases in vagal tone. Alpha adrenergic blockade by phentolamine abolished bradycardia and pressor URs, but not bradycardia CRs. This suggests that separate central mechanisms mediated bradycardia URs and CRs. Removal of the lever diminished without eliminating bradycardia CRs, indicating partial independence between lever lift and cardiac CRs.

AB - Heart rate, blood pressure and lever lifting were studied during differential classical conditioning. The unconditioned stimulus was electrical stimulation of the septal region or the hypothalamus through chronically implanted electrodes; the conditioned stimuli were 2 tones differing in frequency. Beta adrenergic blockade by propranolol did not affect cardiovascular unconditioned responses (URs, bradycardia and pressor response), conditioned responses (CRs, bradycardia), or lever lift responses, whereas cholinergic blockade by atropine methylnitrate abolished heart rate responses but not lever lift responses. This indicates that heart rate responses were mediated by increases in vagal tone. Alpha adrenergic blockade by phentolamine abolished bradycardia and pressor URs, but not bradycardia CRs. This suggests that separate central mechanisms mediated bradycardia URs and CRs. Removal of the lever diminished without eliminating bradycardia CRs, indicating partial independence between lever lift and cardiac CRs.

UR - http://www.scopus.com/inward/record.url?scp=0016347005&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0016347005&partnerID=8YFLogxK

M3 - Chapter

VL - 87

SP - 953

EP - 962

BT - Journal of Comparative and Physiological Psychology

ER -