SELDI-TOF mass spectrometry for cancer biomarker discovery and serum proteomic diagnostics

Fiona Simpkins, Josephine A. Czechowicz, Lance Liotta, Elise C. Kohn

Research output: Contribution to journalArticlepeer-review

38 Scopus citations


Proteomics is more than the identification of proteins that are altered in expression as a consequence of disease. Among the tools critical for the detection, treatment and monitoring of disease are biomarkers. The necessity for new methods to identify and validate biomarkers is underscored by the increased survival of patients diagnosed at early stages of cancer. Serum proteomic pattern diagnostics is a new technique in which proteomic signatures are used as a diagnostic classifier. Surface-enhanced laser desorption/ionization time-of-flight mass spectrometry has shown promise as a modality for biomarker discovery of early-stage cancers. Mass spectrometry-derived protein signatures have been modeled and are now moving into validation. Further sequencing of these key features can lead to new insights into disease etiology and intervention.

Original languageEnglish (US)
Pages (from-to)647-653
Number of pages7
Issue number6
StatePublished - Sep 1 2005


  • Biomarker
  • Mass spectrometry
  • Proteomics

ASJC Scopus subject areas

  • Pharmacology
  • Genetics(clinical)


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