Segregation distortion in inheritance of progressive rod cone degeneration (prcd) in miniature poodle dogs

G. M. Acland, S. Halloran-Blanton, A. Boughman, G. D. Aguirre

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Segregation distortion was observed in inheritance of progressive rod-cone degeneration (prcd) in a colony of Miniature Poodle dogs. Breeding results, from both retrospective records and prospectively planned matings, were classified into five mating types: (1) affected to affected, (2) homozygous normal sire to any dam, (3) heterozygous to heterozygous, (4) heterozygous sire to affected dam, and (5) affected sire to heterozygous dam. For all but the last category, results were in accord with mendelian expectations for autosomal-recessive inheritance. However, litters of mating type 5 had fewer affected pups (20/77) than expected. The observed segregation ratio for this mating type (0.26) was significantly (P < 0.001) less than the expected (0.50). The segregation distortion could not be accounted for by either pre- or postnatal loss of affected pups, as litter size and litter survivability were uniform among litters of different mating types. Either the prcd locus, or a linked locus, would appear to influence either gametic or zygotic fitness in the heterozygous mother. Comparison is drawn to the inheritance of retinitis pigmentosa in humans, in which decreased segregation ratios are also recognized.

Original languageEnglish (US)
Pages (from-to)354-359
Number of pages6
JournalAmerican journal of medical genetics
Volume35
Issue number3
DOIs
StatePublished - Jan 1 1990
Externally publishedYes

Keywords

  • Animal model
  • Dog
  • Gametic selection
  • Hereditary retinal degeneration
  • Miniature poodle
  • Progressive retinal atrophy
  • Retinitis pigmentosa
  • Segregation analysis

ASJC Scopus subject areas

  • Genetics(clinical)

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