Segmentation of prostate and prostate zones using deep learning: A multi-MRI vendor analysis

Olmo Zavala-Romero, Adrian L. Breto, Isaac R. Xu, Yu Cherng C. Chang, Nicole Gautney, Alan Dal Pra, Matthew C. Abramowitz, Alan Pollack, Radka Stoyanova

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


Purpose: Develop a deep-learning-based segmentation algorithm for prostate and its peripheral zone (PZ) that is reliable across multiple MRI vendors. Methods: This is a retrospective study. The dataset consisted of 550 MRIs (Siemens-330, General Electric[GE]-220). A multistream 3D convolutional neural network is used for automatic segmentation of the prostate and its PZ using T2-weighted (T2-w) MRI. Prostate and PZ were manually contoured on axial T2‑w. The network uses axial, coronal, and sagittal T2‑w series as input. The preprocessing of the input data includes bias correction, resampling, and image normalization. A dataset from two MRI vendors (Siemens and GE) is used to test the proposed network. Six different models were trained, three for the prostate and three for the PZ. Of the three, two were trained on data from each vendor separately, and a third (Combined) on the aggregate of the datasets. The Dice coefficient (DSC) is used to compare the manual and predicted segmentation. Results: For prostate segmentation, the Combined model obtained DSCs of 0.893 ± 0.036 and 0.825 ± 0.112 (mean ± standard deviation) on Siemens and GE, respectively. For PZ, the best DSCs were from the Combined model: 0.811 ± 0.079 and 0.788 ± 0.093. While the Siemens model underperformed on the GE dataset and vice versa, the Combined model achieved robust performance on both datasets. Conclusion: The proposed network has a performance comparable to the interexpert variability for segmenting the prostate and its PZ. Combining images from different MRI vendors on the training of the network is of paramount importance for building a universal model for prostate and PZ segmentation.

Original languageEnglish (US)
Pages (from-to)932-942
Number of pages11
JournalStrahlentherapie und Onkologie
Issue number10
StatePublished - Oct 1 2020


  • Convolutional neuro Network
  • Deep learning
  • Peripheral zone
  • Prostate segmentation

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Oncology


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