Segmental outflow of aqueous humor in mouse and human

Teresia A. Carreon, Genea Edwards, Haiyan Wang, Sanjoy K. Bhattacharya

Research output: Contribution to journalReview articlepeer-review

16 Scopus citations


The main and only modifiable risk factor in glaucoma, the group of usually late onset progressive and irreversible blinding optic neuropathies, is elevated intraocular pressure (IOP). The increase in IOP is due to impeded aqueous humor (AH) outflow through the conventional pathway. The aberrant increased resistance at the trabecular meshwork (TM), the filter-like region in the anterior eye chamber is the major contributory factor in causing the impeded outflow. In normal as well as in glaucoma eyes the regions of the TM are divided into areas of high and low flow. The collector channels and distal outflow regions are now increasingly being recognized as potential players in contributing to impede AH outflow. Structural and molecular make-up contributing to the segmental blockage to outflow is likely to provide greater insight. Establishing segmental blockage to outflow in model systems of glaucoma such as the mouse in parallel to human eyes will expand our repertoire of tools for investigation. Further study into this area of interest has the potential to ultimately lead to the development of new therapeutics focused on lowering IOP by targeting the various components of segmental blockage of outflow in the TM and in the distal outflow region.

Original languageEnglish (US)
Pages (from-to)59-66
Number of pages8
JournalExperimental Eye Research
StatePublished - May 1 2017


  • Aqueous humor
  • Basement membrane
  • Extracellular matrix
  • Glaucoma
  • Intraocular pressure
  • Segmental outflow blockage
  • Trabecular meshwork

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience


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