Secretory functions of macrophages in the human pancreatic islet are regulated by endogenous purinergic signaling

Jonathan R. Weitz, Carol Jacques-Silva, Mirza Muhammed Fahd Qadir, Oliver Umland, Elizabeth Pereira, Farhan Qureshi, Alejandro Tamayo, Juan Dominguez-Bendala, Rayner Rodriguez-Diaz, Joana Almaça, Alejandro Caicedo

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Endocrine cells of the pancreatic islet interact with their microenvironment to maintain tissue homeostasis. Com-munication with local macrophages is particularly im-portant in this context, but the homeostatic functions of human islet macrophages are not known. In this study, we show that the human islet contains macrophages in perivascular regions that are the main local source of the anti-inflammatory cytokine interleukin-10 (IL-10) and the metalloproteinase MMP9. Macrophage production and secretion of these homeostatic factors are controlled by endogenous purinergic signals. In obese and diabetic states, macrophage expression of purinergic receptors MMP9 and IL-10 is reduced. We propose that in those states, exacerbated β-cell activity due to increased insulin demand and increased cell death produce high levels of ATP that downregulate purinergic receptor expression. Loss of ATP sensing in macrophages may reduce their secretory capacity.

Original languageEnglish (US)
Pages (from-to)1206-1218
Number of pages13
JournalDiabetes
Volume69
Issue number6
DOIs
StatePublished - Jun 2020

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

Fingerprint Dive into the research topics of 'Secretory functions of macrophages in the human pancreatic islet are regulated by endogenous purinergic signaling'. Together they form a unique fingerprint.

  • Cite this