Secretion of methotrexate into human milk

David G. Johns, Ladd D. Rutherford, Petra C. Leighton, Charles L. Vogel

Research output: Contribution to journalArticlepeer-review

137 Scopus citations


After oral administration to a lactating patient with choriocarcinoma, the cancer chemotherapeutic agent methotrexate (MTX) was found to be excreted in milk at low but readily detectable levels. The highest milk:plasma concentration ratio, 0.08:1, was observed 10 hr. after administration of the drug. The kinetics of the MTX secretion process correspond to those which would be anticipated for a weak organic acid transferred from plasma to milk by passive diffusion of the nonionized form.

Original languageEnglish (US)
Pages (from-to)978-980
Number of pages3
JournalAmerican journal of obstetrics and gynecology
Issue number7
StatePublished - Apr 1 1972
Externally publishedYes

ASJC Scopus subject areas

  • Obstetrics and Gynecology


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