Secretion of Human Prolactin In Vitro

Richard A. Knazek, Jay S. Skyler

Research output: Contribution to journalArticlepeer-review

19 Scopus citations


Cells from two human pituitary tumors were grown in capillary culture units and prolactin production was measured. A single unit could produce 3 mg of prolactin over a 4-month period. The cultured cells responded to TRH exposure by increasing their rate of prolactin secretion. Cultivation of cells in capillary units could be the method of choice for reducing the shortage of human hormones. The authors appreciate the suggestions of Drs. Pie-tro M. Gullino, Andreas Chrambach, and Walter Lov-enberg. We are indebted to Drs. Walter Lockhardt, Frank Neelon, and Tom Huff for obtaining the pituitary tissues. We also thank Mr. Norman Beaudry and Ms. Sharon McAvinue for technical assistance.

Original languageEnglish (US)
Pages (from-to)561-564
Number of pages4
JournalProceedings of the Society for Experimental Biology and Medicine
Issue number3
StatePublished - Mar 1976
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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