Abstract
Cells from two human pituitary tumors were grown in capillary culture units and prolactin production was measured. A single unit could produce 3 mg of prolactin over a 4-month period. The cultured cells responded to TRH exposure by increasing their rate of prolactin secretion. Cultivation of cells in capillary units could be the method of choice for reducing the shortage of human hormones. The authors appreciate the suggestions of Drs. Pie-tro M. Gullino, Andreas Chrambach, and Walter Lov-enberg. We are indebted to Drs. Walter Lockhardt, Frank Neelon, and Tom Huff for obtaining the pituitary tissues. We also thank Mr. Norman Beaudry and Ms. Sharon McAvinue for technical assistance.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 561-564 |
| Number of pages | 4 |
| Journal | Proceedings of the Society for Experimental Biology and Medicine |
| Volume | 151 |
| Issue number | 3 |
| DOIs | |
| State | Published - Mar 1976 |
| Externally published | Yes |
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
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Knazek, R. A., & Skyler, J. S. (1976). Secretion of Human Prolactin In Vitro. Proceedings of the Society for Experimental Biology and Medicine, 151(3), 561-564. https://doi.org/10.3181/00379727-151-39258