Secretion of bladder tumor-derived hyaluronidase activity by invasive bladder tumor cells

Vinata B. Lokeshwar, Mark S. Soloway, Norman L Block

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Hyaluronic acid (HA), a glycosaminoglycan, promotes tumor metastasis and its small fragments are angiogenic. These small fragments are generated by degradation of HA by hyaluronidase (HAase). We measured urinary HAase levels of 196 individuals using an ELISA-like assay. The urinary HAase levels (31.1±3.7mU/mg) of intermediate (G2) to high-grade (G3) bladder cancer patients are five- to seven-fold elevated as compared to those of normal individuals and patients with other genitourinary conditions or low-grade (G1) bladder cancer. The increase in urinary HAase levels is due to the secretion of a tumor-derived HAase which is elevated eight-fold in G2/G3 tumor tissues. The HAase in bladder tumor tissues is secreted by tumor epithelial cells and is associated with the invasive/metastatic potential of the tumor cells. Copyright (C) 1998 Elsevier Science Ireland Ltd.

Original languageEnglish
Pages (from-to)21-27
Number of pages7
JournalCancer Letters
Volume131
Issue number1
DOIs
StatePublished - Sep 11 1998

Fingerprint

Hyaluronoglucosaminidase
Urinary Bladder Neoplasms
Hyaluronic Acid
Neoplasms
Glycosaminoglycans
Epithelial Cells
Enzyme-Linked Immunosorbent Assay
Neoplasm Metastasis

Keywords

  • Bladder cancer marker
  • Hyaluronic acid
  • Hyaluronidase
  • Tumor angiogenesis

ASJC Scopus subject areas

  • Cancer Research
  • Molecular Biology
  • Oncology

Cite this

Secretion of bladder tumor-derived hyaluronidase activity by invasive bladder tumor cells. / Lokeshwar, Vinata B.; Soloway, Mark S.; Block, Norman L.

In: Cancer Letters, Vol. 131, No. 1, 11.09.1998, p. 21-27.

Research output: Contribution to journalArticle

Lokeshwar, Vinata B. ; Soloway, Mark S. ; Block, Norman L. / Secretion of bladder tumor-derived hyaluronidase activity by invasive bladder tumor cells. In: Cancer Letters. 1998 ; Vol. 131, No. 1. pp. 21-27.
@article{d06e02a6b2cf42848ee558967a9dd4ff,
title = "Secretion of bladder tumor-derived hyaluronidase activity by invasive bladder tumor cells",
abstract = "Hyaluronic acid (HA), a glycosaminoglycan, promotes tumor metastasis and its small fragments are angiogenic. These small fragments are generated by degradation of HA by hyaluronidase (HAase). We measured urinary HAase levels of 196 individuals using an ELISA-like assay. The urinary HAase levels (31.1±3.7mU/mg) of intermediate (G2) to high-grade (G3) bladder cancer patients are five- to seven-fold elevated as compared to those of normal individuals and patients with other genitourinary conditions or low-grade (G1) bladder cancer. The increase in urinary HAase levels is due to the secretion of a tumor-derived HAase which is elevated eight-fold in G2/G3 tumor tissues. The HAase in bladder tumor tissues is secreted by tumor epithelial cells and is associated with the invasive/metastatic potential of the tumor cells. Copyright (C) 1998 Elsevier Science Ireland Ltd.",
keywords = "Bladder cancer marker, Hyaluronic acid, Hyaluronidase, Tumor angiogenesis",
author = "Lokeshwar, {Vinata B.} and Soloway, {Mark S.} and Block, {Norman L}",
year = "1998",
month = "9",
day = "11",
doi = "10.1016/S0304-3835(98)00197-9",
language = "English",
volume = "131",
pages = "21--27",
journal = "Cancer Letters",
issn = "0304-3835",
publisher = "Elsevier Ireland Ltd",
number = "1",

}

TY - JOUR

T1 - Secretion of bladder tumor-derived hyaluronidase activity by invasive bladder tumor cells

AU - Lokeshwar, Vinata B.

AU - Soloway, Mark S.

AU - Block, Norman L

PY - 1998/9/11

Y1 - 1998/9/11

N2 - Hyaluronic acid (HA), a glycosaminoglycan, promotes tumor metastasis and its small fragments are angiogenic. These small fragments are generated by degradation of HA by hyaluronidase (HAase). We measured urinary HAase levels of 196 individuals using an ELISA-like assay. The urinary HAase levels (31.1±3.7mU/mg) of intermediate (G2) to high-grade (G3) bladder cancer patients are five- to seven-fold elevated as compared to those of normal individuals and patients with other genitourinary conditions or low-grade (G1) bladder cancer. The increase in urinary HAase levels is due to the secretion of a tumor-derived HAase which is elevated eight-fold in G2/G3 tumor tissues. The HAase in bladder tumor tissues is secreted by tumor epithelial cells and is associated with the invasive/metastatic potential of the tumor cells. Copyright (C) 1998 Elsevier Science Ireland Ltd.

AB - Hyaluronic acid (HA), a glycosaminoglycan, promotes tumor metastasis and its small fragments are angiogenic. These small fragments are generated by degradation of HA by hyaluronidase (HAase). We measured urinary HAase levels of 196 individuals using an ELISA-like assay. The urinary HAase levels (31.1±3.7mU/mg) of intermediate (G2) to high-grade (G3) bladder cancer patients are five- to seven-fold elevated as compared to those of normal individuals and patients with other genitourinary conditions or low-grade (G1) bladder cancer. The increase in urinary HAase levels is due to the secretion of a tumor-derived HAase which is elevated eight-fold in G2/G3 tumor tissues. The HAase in bladder tumor tissues is secreted by tumor epithelial cells and is associated with the invasive/metastatic potential of the tumor cells. Copyright (C) 1998 Elsevier Science Ireland Ltd.

KW - Bladder cancer marker

KW - Hyaluronic acid

KW - Hyaluronidase

KW - Tumor angiogenesis

UR - http://www.scopus.com/inward/record.url?scp=0032508712&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032508712&partnerID=8YFLogxK

U2 - 10.1016/S0304-3835(98)00197-9

DO - 10.1016/S0304-3835(98)00197-9

M3 - Article

VL - 131

SP - 21

EP - 27

JO - Cancer Letters

JF - Cancer Letters

SN - 0304-3835

IS - 1

ER -