Secondhand smoke exposure and C-reactive protein levels in youth

James D. Wilkinson, David J. Lee, Kristopher L. Arheart

Research output: Contribution to journalArticlepeer-review

29 Scopus citations


Using data from the National Health and Nutrition Examination Survey (NHANES, 1999-2002), we examined the association of secondhand tobacco exposure, estimated by serum cotinine, with serum C-reactive protein (CRP) concentrations in nonsmoking participants, aged 6-18 years. The association between serum cotinine and serum CRP was analyzed using multiple linear regression, with adjustment for other study variables. All analyses used weighted data and adjustments for design effects. Multiple regression analysis indicated that a change in serum cotinine of 0.5 ng/ml was associated with a 0.96 mg/dl change in CRP (95% CI=0.93-1.00), even after adjustment for age, white blood cell count, and body mass index percentile. We found a significant association between secondhand smoke exposure, assessed by serum cotinine, and elevated serum CRP among nonsmoking youth. Secondhand smoke exposure may pose an important long-term cardiovascular risk for children and adolescents.

Original languageEnglish (US)
Pages (from-to)305-307
Number of pages3
JournalNicotine and Tobacco Research
Issue number2
StatePublished - Feb 1 2007

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health


Dive into the research topics of 'Secondhand smoke exposure and C-reactive protein levels in youth'. Together they form a unique fingerprint.

Cite this