Secondary hypoxia following moderate fluid percussion brain injury in rats exacerbates sensorimotor and cognitive deficits

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

Human head trauma is frequently associated with respiratory problems resulting in secondary hypoxic insult. To document the behavioral consequences of secondary hypoxia in an established model of traumatic brain injury (TBI), intubated anesthetized animals were subjected to fluid percussion (FP) injury (1.87-2.17 atm) followed by 30 min of either normoxic (TBI-NO, n = 10) or hypoxic (TBI-HY, n = 11; pO2 = 30-40 mm Hg) gas levels. Sham animals (n = 19) underwent all manipulations except for the actual trauma. Animals were tested on various sensorimotor tasks beginning 3 days after FP injury along with cognitive testing on days 22 through 29 posttrauma. The secondary hypoxic insult exacerbated the sensorimotor deficits on beam-walking compared to those animals only receiving trauma. Cognitive impairments were also observed in the TBI-HY group in the hidden platform task compared to FP injury alone. These data indicate that a secondary hypoxic insult exacerbates both sensorimotor and cognitive deficits after TBI. This study provides direct evidence that incidences of hypoxia after brain trauma may potentially result in an increase in neurological deficits for the subpopulation of head injured patients undergoing hypoxic conditions further warranting strict monitoring of these events.

Original languageEnglish
Pages (from-to)1035-1047
Number of pages13
JournalJournal of Neurotrauma
Volume16
Issue number11
StatePublished - Nov 1 1999

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Percussion
Brain Injuries
Wounds and Injuries
Craniocerebral Trauma
Walking
Traumatic Brain Injury
Hypoxia
Gases
Head
Incidence

Keywords

  • Fluid percussion
  • Hypoxia
  • Morris water maze
  • Rats
  • Sensorimotor task
  • Traumatic brain injury

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Secondary hypoxia following moderate fluid percussion brain injury in rats exacerbates sensorimotor and cognitive deficits. / Bramlett, Helen; Dalton Dietrich, W.; Green, Edward J.

In: Journal of Neurotrauma, Vol. 16, No. 11, 01.11.1999, p. 1035-1047.

Research output: Contribution to journalArticle

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