Secondary hyperparathyroidism in x-linked hypophosphatemic mice

Gary M. Kiebzak, Bernard A. Roos, Ralph A. Meyer

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Abstract

Plasma parathyroid hormone (PTH) was measured in adult, age-matched, intact normal mice and Hyp male mice (n = 11/genotype). Hyp mice are an animal model for the human disease X-linked hypophosphatemia. A RIA was used which detects intact and carboxyl-terminal fragments of PTH. Hyp mice were found to have significantly higher plasma PTH levels (0.21 +/- 0.03 ng bovine PTH eq/ml) than normal mice (0.04 +/- 0.03 ng/ml; P less than 0.01). This hyperparathyroidism in the slightly hypocalcemic, osteomalacic Hyp mice may be the result of skeletal resistance to endogenous PTH and may contribute to their characteristically elevated renal excretion of phosphate and urinary cAMP

Original languageEnglish (US)
Pages (from-to)650-652
Number of pages3
JournalEndocrinology
Volume111
Issue number2
DOIs
StatePublished - Aug 1982

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ASJC Scopus subject areas

  • Endocrinology

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