Second primary neoplasms among 53 159 haematolymphoproliferative malignancy patients in Sweden, 1958-1996: A search for common mechanisms

Chuanhui Dong, K. Hemminki

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145 Citations (Scopus)

Abstract

The Swedish Family-Cancer Database was used to analyse site-specific risk of second primary malignancies following 53 159 haematolymphoproliferative disorders (HLPD) diagnosed between 1958 and 1996. Standardized incidence ratio (SIR) of a second malignancy was calculated as the ratio of observed to expected numbers of second malignancies by applying site-, sex-, age-, period-, residence- and occupation-specific rates in the corresponding population in the Database to the appropriate person-years at risk. Among 18 960 patients with non-Hodgkin's lymphoma (NHL), there was over a 3-fold significant increase in cancer of the tongue, small intestine, nose, kidney and nervous system, squamous cell carcinoma (SCC) of the skin, NHL, Hodgkin's disease (HD) and lymphoid and myeloid leukaemia. Among 5353 patients with HD, there was over a 4-fold significant increase in cancer of the salivary glands, nasopharynx and thyroid, NHL and myeloid leukaemia, and over a 1.6-fold increase in cancer of the stomach, colon, lung, breast, skin (melanoma and SCC), nervous system and soft tissues and lymphoid leukaemia. Among 28 846 patients with myeloma and leukaemia, there was a significant increase in cancer of the skin, nervous system and non-thyroid endocrine glands and all HLPD except for myeloma. Our findings showed some clustering between first and second primaries among Epstein-Barr virus-, ultraviolet radiation- and immunosuppression-related cancers.

Original languageEnglish
Pages (from-to)997-1005
Number of pages9
JournalBritish Journal of Cancer
Volume85
Issue number7
DOIs
StatePublished - Sep 28 2001
Externally publishedYes

Fingerprint

Second Primary Neoplasms
Sweden
Non-Hodgkin's Lymphoma
Nervous System
Lymphoid Leukemia
Myeloid Leukemia
Hodgkin Disease
Squamous Cell Carcinoma
Salivary Gland Neoplasms
Databases
Tongue Neoplasms
Endocrine Glands
Neoplasms
Skin
Nasopharynx
Skin Neoplasms
Human Herpesvirus 4
Nose
Occupations
Colonic Neoplasms

Keywords

  • Epstein-Barr virus
  • Follow-up study
  • Haematolymphoproliferative disorders
  • Immunosuppression
  • Second malignancies

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

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title = "Second primary neoplasms among 53 159 haematolymphoproliferative malignancy patients in Sweden, 1958-1996: A search for common mechanisms",
abstract = "The Swedish Family-Cancer Database was used to analyse site-specific risk of second primary malignancies following 53 159 haematolymphoproliferative disorders (HLPD) diagnosed between 1958 and 1996. Standardized incidence ratio (SIR) of a second malignancy was calculated as the ratio of observed to expected numbers of second malignancies by applying site-, sex-, age-, period-, residence- and occupation-specific rates in the corresponding population in the Database to the appropriate person-years at risk. Among 18 960 patients with non-Hodgkin's lymphoma (NHL), there was over a 3-fold significant increase in cancer of the tongue, small intestine, nose, kidney and nervous system, squamous cell carcinoma (SCC) of the skin, NHL, Hodgkin's disease (HD) and lymphoid and myeloid leukaemia. Among 5353 patients with HD, there was over a 4-fold significant increase in cancer of the salivary glands, nasopharynx and thyroid, NHL and myeloid leukaemia, and over a 1.6-fold increase in cancer of the stomach, colon, lung, breast, skin (melanoma and SCC), nervous system and soft tissues and lymphoid leukaemia. Among 28 846 patients with myeloma and leukaemia, there was a significant increase in cancer of the skin, nervous system and non-thyroid endocrine glands and all HLPD except for myeloma. Our findings showed some clustering between first and second primaries among Epstein-Barr virus-, ultraviolet radiation- and immunosuppression-related cancers.",
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