Second malignancies in multiple myeloma; emerging patterns and future directions

Kylee Maclachlan, Benjamin Diamond, Francesco Maura, Jens Hillengass, Ingemar Turesson, C. Ola Landgren, Dickran Kazandjian

Research output: Contribution to journalReview articlepeer-review

8 Scopus citations

Abstract

The changing landscape of treatment options for multiple myeloma has led to a higher proportion of patients achieving deep, long-lasting responses to therapy. With the associated improvement in overall survival, the development of subsequent second malignancies has become of increased significance. The risk of second malignancy after multiple myeloma is affected by a combination of patient-, disease- and therapy-related risk factors. This review discusses recent data refining our knowledge of these contributing factors, including current treatment modalities which increase risk (i.e. high-dose melphalan with autologous stem cell transplant and lenalidomide maintenance therapy). We highlight emerging data towards individualized risk- and response-adapted treatment strategies and discuss key areas requiring future research.

Original languageEnglish (US)
Article number101144
JournalBest Practice and Research: Clinical Haematology
Volume33
Issue number1
DOIs
StatePublished - Mar 2020
Externally publishedYes

Keywords

  • Autologous
  • Lenalidomide
  • Melphalan
  • Multiple myeloma
  • Neoplasms
  • Risk factors
  • Second primary
  • Transplantation

ASJC Scopus subject areas

  • Oncology
  • Clinical Biochemistry

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