Seasonality, parasite diversity, and local extinctions in Plasmodium falciparum malaria

F. Ellis McKenzie, Gerry F. Killeen, John C. Beier, William H. Bossert

Research output: Contribution to journalArticle

36 Scopus citations

Abstract

We incorporate stochastic, density-dependent seasonal recruitment in adult Anopheles mosquito populations in a discrete-event model of Plasmodium falciparum malaria transmission and find the probabilities of parasite extinction higher than with perennial transmission. Seasonal fluctuations in vector populations act to synchronize the dynamics of infection and immunity in host populations, leading to fluctuations in parasite prevalence greater than expected solely on the basis of high- and low-season vector densities. This synchronization also biases frequencies of infection with multiple parasite phenotypes or genotypes.

Original languageEnglish (US)
Pages (from-to)2673-2681
Number of pages9
JournalEcology
Volume82
Issue number10
DOIs
StatePublished - Jan 1 2001

Keywords

  • Host
  • Infection
  • Local extinction
  • Malaria
  • Parasite
  • Seasonal
  • Transmission
  • Vector

ASJC Scopus subject areas

  • Ecology

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