Seasonal transmission dynamics of measles in China

Jicai Huang, Shigui Ruan, Xiao Wu, Xuelei Zhou

Research output: Contribution to journalArticle

Abstract

Measles, a highly contagious infection caused by the measles virus, is a major public health problem in China. The reported measles cases decreased dramatically from 2004 to 2012 due to the mandatory measles vaccine program started in 2005 and the goal of eliminating measles by 2012. However, after reaching its lowest level in 2012, measles has resurged again since 2013. Since the monthly data of measles cases exhibit a seasonally fluctuating pattern, based on the measles model in Earn et al. (Science 287:667–670, 2000), we propose a susceptible, exposed, infectious, and recovered model with periodic transmission rate to investigate the seasonal measles epidemics and the effect of vaccination. We calculate the basic reproduction number R0, analyze the dynamical behavior of the model, and use the model to simulate the monthly data of measles cases reported in China. We also carry out some sensitivity analysis of R0 in the terms of various model parameters which shows that measles can be controlled and eventually eradicated by increasing the immunization rate, improving the effective vaccine management, and enhancing the awareness of people about measles.

Original languageEnglish (US)
JournalTheory in Biosciences
DOIs
StateAccepted/In press - Jan 1 2018

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measles
China
Vaccines
Vaccine
vaccines
Measles virus
Immunization
Basic Reproduction number
Model
Vaccination
Public Health
Public health
Medical problems
Viruses
Dynamical Behavior
Sensitivity analysis
Virus
vaccine
Sensitivity Analysis
Infection

Keywords

  • Basic reproduction number
  • Measles
  • Periodic solution
  • SEIR model
  • Vaccination

ASJC Scopus subject areas

  • Statistics and Probability
  • Ecology, Evolution, Behavior and Systematics
  • Applied Mathematics

Cite this

Seasonal transmission dynamics of measles in China. / Huang, Jicai; Ruan, Shigui; Wu, Xiao; Zhou, Xuelei.

In: Theory in Biosciences, 01.01.2018.

Research output: Contribution to journalArticle

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