Searching for the origin of the enigmatic circulating T follicular helper cells

Research output: Contribution to journalReview article

1 Scopus citations

Abstract

T follicular helper (Tfh) cells in germinal centers of secondary lymphoid organs are pivotal for B and T cell interactions required for induction of humoral immunity. It has long been debated whether Tfh cells exit from lymph nodes into the blood as circulating Tfh cells. In this issue of the JCI, Vella et al. have taken the bull by the horns and applied considerable technical muscle to answer this question. By analyzing phenotype, transcriptome, epigenetic profile, and T cell receptor clonotype, the authors provide evidence that a subset of cTfh cells do indeed originate in lymph nodes and traffic into the blood via the thoracic duct.

Original languageEnglish (US)
Pages (from-to)3048-3051
Number of pages4
JournalJournal of Clinical Investigation
Volume129
Issue number8
DOIs
StatePublished - Aug 1 2019

ASJC Scopus subject areas

  • Medicine(all)

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