Search for a gene that predisposes individuals to BPI disorder

Daniela S. Gerhard; Janice A. Egeland; David L. Pauls; David E. Housman

doi:10.1016/0022-3956(87)90106-3

Search for a gene that predisposes individuals to BPI disorder

Daniela S. Gerhard, Janice A. Egeland, David L. Pauls, David E. Housman

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

To determine the role of genetics in bipolar affective disorders it was necessary to have correct diagnosis and large homogenous population(s). To identify a marker linked to the disease two additional factors were important, a correct model for genetic transmission and highly polymorphic DNA markers. With the establishment of a linked marker the aim is to identify the susceptibility gene. Two approaches are the prediction of candidate genes and/or the determination of a physical map of the region.

Original language	English (US)
Pages (from-to)	569-575
Number of pages	7
Journal	Journal of Psychiatric Research
Volume	21
Issue number	4
DOIs	https://doi.org/10.1016/0022-3956(87)90106-3
State	Published - 1987
Externally published	Yes

ASJC Scopus subject areas

Psychiatry and Mental health
Biological Psychiatry

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10.1016/0022-3956(87)90106-3

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@article{239d9d713d654b02b8b51ed0f498709f,

title = "Search for a gene that predisposes individuals to BPI disorder",

abstract = "To determine the role of genetics in bipolar affective disorders it was necessary to have correct diagnosis and large homogenous population(s). To identify a marker linked to the disease two additional factors were important, a correct model for genetic transmission and highly polymorphic DNA markers. With the establishment of a linked marker the aim is to identify the susceptibility gene. Two approaches are the prediction of candidate genes and/or the determination of a physical map of the region.",

author = "Gerhard, {Daniela S.} and Egeland, {Janice A.} and Pauls, {David L.} and Housman, {David E.}",

note = "Funding Information: Acknowledgements--This work was supported by grants from the National Institutes of Mental Health, MH28287 and MH00508, and from the National Institutes of Health GM27882. DLP was supported by an RSDA award from NIMH and DSG by a postdoctoral fellowship from Damon Runyon-Walter Winchell Foundation DRG-665. We are indebted to Jen Cunningham whose superb secretarial skills were instrumental in the preparation of this manuscript.",

year = "1987",

doi = "10.1016/0022-3956(87)90106-3",

language = "English (US)",

volume = "21",

pages = "569--575",

journal = "Journal of Psychiatric Research",

issn = "0022-3956",

publisher = "Elsevier Limited",

number = "4",

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T1 - Search for a gene that predisposes individuals to BPI disorder

AU - Gerhard, Daniela S.

AU - Egeland, Janice A.

AU - Pauls, David L.

AU - Housman, David E.

N1 - Funding Information: Acknowledgements--This work was supported by grants from the National Institutes of Mental Health, MH28287 and MH00508, and from the National Institutes of Health GM27882. DLP was supported by an RSDA award from NIMH and DSG by a postdoctoral fellowship from Damon Runyon-Walter Winchell Foundation DRG-665. We are indebted to Jen Cunningham whose superb secretarial skills were instrumental in the preparation of this manuscript.

PY - 1987

Y1 - 1987

N2 - To determine the role of genetics in bipolar affective disorders it was necessary to have correct diagnosis and large homogenous population(s). To identify a marker linked to the disease two additional factors were important, a correct model for genetic transmission and highly polymorphic DNA markers. With the establishment of a linked marker the aim is to identify the susceptibility gene. Two approaches are the prediction of candidate genes and/or the determination of a physical map of the region.

AB - To determine the role of genetics in bipolar affective disorders it was necessary to have correct diagnosis and large homogenous population(s). To identify a marker linked to the disease two additional factors were important, a correct model for genetic transmission and highly polymorphic DNA markers. With the establishment of a linked marker the aim is to identify the susceptibility gene. Two approaches are the prediction of candidate genes and/or the determination of a physical map of the region.

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JO - Journal of Psychiatric Research

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Search for a gene that predisposes individuals to BPI disorder

Abstract

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