Screening of mouse connexin 31 genomic clone and mapping by fluorescence in situ hybridization

W. Z. Li; Z. G. Xue; G. Wang

Screening of mouse connexin 31 genomic clone and mapping by fluorescence in situ hybridization

W. Z. Li, Z. G. Xue, G. Wang

Research output: Contribution to journal › Article › peer-review

Abstract

Connexin 31(Cx31) is one of the human genetic deafness disease genes. To determine the structure and function of Cx31 gene of mouse, the mouse Cx31 gene clone was screened from the genomic library with the probe obtained according to the sequence of the mouse Cx31 gene cDNA. Cx31 gene was mapped to the center of mouse chromosome 4 by fluorescence in situ hybridization. The present study lays a foundation for researches on structure and function of Cx31 gene, as well as establishment of the relative transgenic mice and gene knockout mice.

Original language	English (US)
Pages (from-to)	499-501
Number of pages	3
Journal	Hunan yi ke da xue xue bao = Hunan yike daxue xuebao = Bulletin of Hunan Medical University
Volume	26
Issue number	6
State	Published - Dec 28 2001
Externally published	Yes

ASJC Scopus subject areas

Medicine(all)

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title = "Screening of mouse connexin 31 genomic clone and mapping by fluorescence in situ hybridization",

abstract = "Connexin 31(Cx31) is one of the human genetic deafness disease genes. To determine the structure and function of Cx31 gene of mouse, the mouse Cx31 gene clone was screened from the genomic library with the probe obtained according to the sequence of the mouse Cx31 gene cDNA. Cx31 gene was mapped to the center of mouse chromosome 4 by fluorescence in situ hybridization. The present study lays a foundation for researches on structure and function of Cx31 gene, as well as establishment of the relative transgenic mice and gene knockout mice.",

author = "Li, {W. Z.} and Xue, {Z. G.} and G. Wang",

year = "2001",

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language = "English (US)",

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AU - Li, W. Z.

AU - Xue, Z. G.

AU - Wang, G.

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N2 - Connexin 31(Cx31) is one of the human genetic deafness disease genes. To determine the structure and function of Cx31 gene of mouse, the mouse Cx31 gene clone was screened from the genomic library with the probe obtained according to the sequence of the mouse Cx31 gene cDNA. Cx31 gene was mapped to the center of mouse chromosome 4 by fluorescence in situ hybridization. The present study lays a foundation for researches on structure and function of Cx31 gene, as well as establishment of the relative transgenic mice and gene knockout mice.

AB - Connexin 31(Cx31) is one of the human genetic deafness disease genes. To determine the structure and function of Cx31 gene of mouse, the mouse Cx31 gene clone was screened from the genomic library with the probe obtained according to the sequence of the mouse Cx31 gene cDNA. Cx31 gene was mapped to the center of mouse chromosome 4 by fluorescence in situ hybridization. The present study lays a foundation for researches on structure and function of Cx31 gene, as well as establishment of the relative transgenic mice and gene knockout mice.

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