Scleroderma esophagus: A nonspecific entity

H. A. Schneider, R. A. Yonker, S. Longley, P. Katz, J. Mathias, R. S. Panush

Research output: Contribution to journalArticlepeer-review

33 Scopus citations


Esophageal dysfunction develops in approximately 90% of patients with progressive systemic sclerosis (scleroderma) or mixed connective tissue disease. Abnormal esophageal motility may be one of the earliest manifestations of scleroderma because of smooth muscle involvement. Smooth muscle is found in the lower two thirds of the esophagus and in the lower esophageal sphincter. Manometric measurements confirm the incoordination and loss of effective contractions that often progress to complete absence of esophageal contractions and reduced lower esophageal splhincter tone. We reviewed esophageal manometric tracings from patients with or without rheumatic disease to determine whether low-amplitude aperistalsis or a low-pressure lower sphincter was specific for scleroderma or mixed connective tissue disease. We found these changes were not unique to these disorders.

Original languageEnglish (US)
Pages (from-to)848-850
Number of pages3
JournalAnnals of internal medicine
Issue number6
StatePublished - Jan 1 1984

ASJC Scopus subject areas

  • Internal Medicine


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