Abstract
The population impact of sudden death remains an unresolved problem despite growing insights into pathophysiologic mechanisms and therapeutic approaches. To make further progress, basic scientists, clinical investigators, and epidemiologists must merge their efforts to achieve better predictive strategies. Better understanding of basic physiologic mechanisms and integration of multiple points of attack in the cascade of coronary atherosclerosis are required. Identification of genetic markers of risk at all levels of the cascade offer one avenue for improving risk predictions. The epidemiologic strategies must go beyond multivariate analysis to the level complex systems analysis of the multiple components of the cascade. Targets for such approaches are discussed.
| Original language | English |
|---|---|
| Pages (from-to) | 709-723 |
| Number of pages | 15 |
| Journal | Journal of Cardiovascular Electrophysiology |
| Volume | 13 |
| Issue number | 7 |
| State | Published - Jul 25 2002 |
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Keywords
- Arrhythmia
- Epidemiology
- Genetics
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
- Physiology
Cite this
Scientific gaps in the prediction and prevention of sudden cardiac death. / Myerburg, Robert J.
In: Journal of Cardiovascular Electrophysiology, Vol. 13, No. 7, 25.07.2002, p. 709-723.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Scientific gaps in the prediction and prevention of sudden cardiac death
AU - Myerburg, Robert J
PY - 2002/7/25
Y1 - 2002/7/25
N2 - The population impact of sudden death remains an unresolved problem despite growing insights into pathophysiologic mechanisms and therapeutic approaches. To make further progress, basic scientists, clinical investigators, and epidemiologists must merge their efforts to achieve better predictive strategies. Better understanding of basic physiologic mechanisms and integration of multiple points of attack in the cascade of coronary atherosclerosis are required. Identification of genetic markers of risk at all levels of the cascade offer one avenue for improving risk predictions. The epidemiologic strategies must go beyond multivariate analysis to the level complex systems analysis of the multiple components of the cascade. Targets for such approaches are discussed.
AB - The population impact of sudden death remains an unresolved problem despite growing insights into pathophysiologic mechanisms and therapeutic approaches. To make further progress, basic scientists, clinical investigators, and epidemiologists must merge their efforts to achieve better predictive strategies. Better understanding of basic physiologic mechanisms and integration of multiple points of attack in the cascade of coronary atherosclerosis are required. Identification of genetic markers of risk at all levels of the cascade offer one avenue for improving risk predictions. The epidemiologic strategies must go beyond multivariate analysis to the level complex systems analysis of the multiple components of the cascade. Targets for such approaches are discussed.
KW - Arrhythmia
KW - Epidemiology
KW - Genetics
UR - http://www.scopus.com/inward/record.url?scp=0035996747&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0035996747&partnerID=8YFLogxK
M3 - Article
C2 - 12139299
AN - SCOPUS:0035996747
VL - 13
SP - 709
EP - 723
JO - Journal of Cardiovascular Electrophysiology
JF - Journal of Cardiovascular Electrophysiology
SN - 1045-3873
IS - 7
ER -