Scc1 (CP0432) and Scc4 (CP0033) function as a type III secretion chaperone for CopN of Chlamydia pneumoniae

Eugenia Silva-Herzog, Sabrina S. Joseph, Ann K. Avery, Jose A. Coba, Katerina Wolf, Kenneth A. Fields, Gregory V. Plano

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

The Chlamydia pneumoniae CopN protein is a member of the YopN/TyeA/InvE/MxiC family of secreted proteins that function to regulate the secretion of type III secretion system (T3SS) translocator and effector proteins. In this study, the Scc1 (CP0432) and Scc4 (CP0033) proteins of C. pneumoniae AR-39 were demonstrated to function together as a type III secretion chaperone that binds to an N-terminal region of CopN. The Scc1/Scc4 chaperone promoted the efficient secretion of CopN via a heterologous T3SS, whereas, the Scc3 chaperone, which binds to a C-terminal region of CopN, reduced CopN secretion.

Original languageEnglish (US)
Pages (from-to)3490-3496
Number of pages7
JournalJournal of bacteriology
Volume193
Issue number14
DOIs
StatePublished - Jul 2011

ASJC Scopus subject areas

  • Microbiology
  • Molecular Biology

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