Scavenger receptor regulation and atherosclerosis

Jean Marc Zingg, Roberta Ricciarelli, Angelo Azzi

Research output: Contribution to journalArticlepeer-review

22 Scopus citations

Abstract

Atherosclerosis and its complications, such as coronary heart disease, heart infarction and stroke, are the leading causes of death in the developed world. High blood pressure, diabetes, smoking and a diet high in cholesterol and lipids clearly increase the likelihood of premature atherosclerosis, albeit other factors, such as the individual genetic makeup, may play an additional role. During atherosclerosis, uncontrolled cholesterol and lipid accumulation in macrophages and smooth muscle cells leads to foam cell formation and to the progression of the atherosclerotic plaque. This review will focus on foam cell formation within the atherosclerotic lesion, the involvement of the scavenger receptor genes in this process, and the possibility to interfere with scavenger receptor function to reduce the progression of atherosclerosis. To date, the regulatory mechanisms for the expression of scavenger receptor genes and their role in atherosclerosis are not well characterized. Knowledge on this subject could lead to a better understanding of the process, prevention and therapy of this disease.

Original languageEnglish (US)
Pages (from-to)189-200
Number of pages12
JournalBioFactors
Volume11
Issue number3
DOIs
StatePublished - 2000
Externally publishedYes

Keywords

  • Atherosclerosis
  • Gene expression
  • Scavenger receptors

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Clinical Biochemistry

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