'Vernarbende' Alopezien Anmerkungen zur Klassifikation, Differentialdiagnose und Pathobiologie

Translated title of the contribution: 'Scarring' alopecia. Aspects of classification, differential diagnosis and pathobiology

Barbara Hermes, Ralf Paus

Research output: Contribution to journalReview article

26 Citations (Scopus)

Abstract

Numerous different diseases lead to scarring alopecia with irreversible follicular destruction as a common ending. Current classifications are based on clinical, histopathological or prognostic parameters, as well as on pathogenetic criteria which allow only a rough assessment because the precise mechanisms leading to scarring alopecia are still unknown. Inadequacies of the established classifications are obvious when regarding special forms of scarring alopecia like lichen planopilaris or pseudopelade Brocq. In order to develop more satisfying classifications, recent insights into biology and pathology of the hair follicle and follicular cycling have to be considered. The most important structures for the survival of the hair follicle are the epithelial stem cells which reside in the follicular bulge and the fibroblasts of the dermal papilla including the molecular communication between these two cell populations. Research in the field of scarring alopecia should aim at defining the pathological processes on any of the above mentioned levels which will lead to an irreversible damage of the hair follicle thus allowing the development of new therapeutic agents.

Original languageGerman
Pages (from-to)462-472
Number of pages11
JournalHautarzt
Volume49
Issue number6
DOIs
StatePublished - Jun 1 1998
Externally publishedYes

Fingerprint

Alopecia
Cicatrix
Differential Diagnosis
Hair Follicle
Lichens
Pathologic Processes
Stem Cells
Fibroblasts
Epithelial Cells
Pathology
Skin
Research
Population

Keywords

  • Dermal papilla
  • Dermal- epidermal interaction
  • Follicular bulge
  • Lichen planopilaris
  • Pseudopelade

ASJC Scopus subject areas

  • Dermatology

Cite this

'Vernarbende' Alopezien Anmerkungen zur Klassifikation, Differentialdiagnose und Pathobiologie. / Hermes, Barbara; Paus, Ralf.

In: Hautarzt, Vol. 49, No. 6, 01.06.1998, p. 462-472.

Research output: Contribution to journalReview article

@article{53712000f89b44fd9b6ca5efd330da1e,
title = "'Vernarbende' Alopezien Anmerkungen zur Klassifikation, Differentialdiagnose und Pathobiologie",
abstract = "Numerous different diseases lead to scarring alopecia with irreversible follicular destruction as a common ending. Current classifications are based on clinical, histopathological or prognostic parameters, as well as on pathogenetic criteria which allow only a rough assessment because the precise mechanisms leading to scarring alopecia are still unknown. Inadequacies of the established classifications are obvious when regarding special forms of scarring alopecia like lichen planopilaris or pseudopelade Brocq. In order to develop more satisfying classifications, recent insights into biology and pathology of the hair follicle and follicular cycling have to be considered. The most important structures for the survival of the hair follicle are the epithelial stem cells which reside in the follicular bulge and the fibroblasts of the dermal papilla including the molecular communication between these two cell populations. Research in the field of scarring alopecia should aim at defining the pathological processes on any of the above mentioned levels which will lead to an irreversible damage of the hair follicle thus allowing the development of new therapeutic agents.",
keywords = "Dermal papilla, Dermal- epidermal interaction, Follicular bulge, Lichen planopilaris, Pseudopelade",
author = "Barbara Hermes and Ralf Paus",
year = "1998",
month = "6",
day = "1",
doi = "10.1007/s001050050771",
language = "German",
volume = "49",
pages = "462--472",
journal = "Der Hautarzt",
issn = "0017-8470",
publisher = "Springer Verlag",
number = "6",

}

TY - JOUR

T1 - 'Vernarbende' Alopezien Anmerkungen zur Klassifikation, Differentialdiagnose und Pathobiologie

AU - Hermes, Barbara

AU - Paus, Ralf

PY - 1998/6/1

Y1 - 1998/6/1

N2 - Numerous different diseases lead to scarring alopecia with irreversible follicular destruction as a common ending. Current classifications are based on clinical, histopathological or prognostic parameters, as well as on pathogenetic criteria which allow only a rough assessment because the precise mechanisms leading to scarring alopecia are still unknown. Inadequacies of the established classifications are obvious when regarding special forms of scarring alopecia like lichen planopilaris or pseudopelade Brocq. In order to develop more satisfying classifications, recent insights into biology and pathology of the hair follicle and follicular cycling have to be considered. The most important structures for the survival of the hair follicle are the epithelial stem cells which reside in the follicular bulge and the fibroblasts of the dermal papilla including the molecular communication between these two cell populations. Research in the field of scarring alopecia should aim at defining the pathological processes on any of the above mentioned levels which will lead to an irreversible damage of the hair follicle thus allowing the development of new therapeutic agents.

AB - Numerous different diseases lead to scarring alopecia with irreversible follicular destruction as a common ending. Current classifications are based on clinical, histopathological or prognostic parameters, as well as on pathogenetic criteria which allow only a rough assessment because the precise mechanisms leading to scarring alopecia are still unknown. Inadequacies of the established classifications are obvious when regarding special forms of scarring alopecia like lichen planopilaris or pseudopelade Brocq. In order to develop more satisfying classifications, recent insights into biology and pathology of the hair follicle and follicular cycling have to be considered. The most important structures for the survival of the hair follicle are the epithelial stem cells which reside in the follicular bulge and the fibroblasts of the dermal papilla including the molecular communication between these two cell populations. Research in the field of scarring alopecia should aim at defining the pathological processes on any of the above mentioned levels which will lead to an irreversible damage of the hair follicle thus allowing the development of new therapeutic agents.

KW - Dermal papilla

KW - Dermal- epidermal interaction

KW - Follicular bulge

KW - Lichen planopilaris

KW - Pseudopelade

UR - http://www.scopus.com/inward/record.url?scp=0032087318&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032087318&partnerID=8YFLogxK

U2 - 10.1007/s001050050771

DO - 10.1007/s001050050771

M3 - Review article

VL - 49

SP - 462

EP - 472

JO - Der Hautarzt

JF - Der Hautarzt

SN - 0017-8470

IS - 6

ER -