Scarring alopecia and the PPAR-γ connection

Matthew J. Harries, Ralf Paus

Research output: Contribution to journalComment/debate

30 Citations (Scopus)

Abstract

The pathobiology of primary cicatricial ("scarring") alopecia (PCA) remains poorly understood and underinvestigated. In this issue, Karnik et al. identify a previously unsuspected player, peroxisome proliferator-activated receptor-γ (PPARγ), in the pathogenesis of the most frequent form of PCA, lichen planopilaris (LPP). The authors show that PPARγ is required for maintenance of a functional epithelial stem cell compartment in murine hair follicles, that the targeted deletion of PPARγ in the bulge/isthmus area of the hair follicle epithelium generates a skin pathology that resembles LPP, and that LPP patients show gene expression changes that indicate a defect in lipid metabolism and peroxisome biogenesis. This study invites the revisitation of many open questions in PCA pathobiology and the exploration of new avenues for future PCA management.

Original languageEnglish (US)
Pages (from-to)1066-1070
Number of pages5
JournalJournal of Investigative Dermatology
Volume129
Issue number5
DOIs
StatePublished - Jan 1 2009
Externally publishedYes

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Passive Cutaneous Anaphylaxis
Peroxisome Proliferator-Activated Receptors
Alopecia
Lichens
Cicatrix
Hair Follicle
Pathology
Stem cells
Gene expression
Peroxisomes
Skin
Lipid Metabolism
Defects
Stem Cells
Epithelium
Epithelial Cells
Maintenance
Gene Expression

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Dermatology
  • Cell Biology

Cite this

Scarring alopecia and the PPAR-γ connection. / Harries, Matthew J.; Paus, Ralf.

In: Journal of Investigative Dermatology, Vol. 129, No. 5, 01.01.2009, p. 1066-1070.

Research output: Contribution to journalComment/debate

Harries, Matthew J. ; Paus, Ralf. / Scarring alopecia and the PPAR-γ connection. In: Journal of Investigative Dermatology. 2009 ; Vol. 129, No. 5. pp. 1066-1070.
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