Scarring alopecia and the PPAR-γ connection

Matthew J. Harries, Ralf Paus

Research output: Contribution to journalComment/debate

33 Scopus citations

Abstract

The pathobiology of primary cicatricial ("scarring") alopecia (PCA) remains poorly understood and underinvestigated. In this issue, Karnik et al. identify a previously unsuspected player, peroxisome proliferator-activated receptor-γ (PPARγ), in the pathogenesis of the most frequent form of PCA, lichen planopilaris (LPP). The authors show that PPARγ is required for maintenance of a functional epithelial stem cell compartment in murine hair follicles, that the targeted deletion of PPARγ in the bulge/isthmus area of the hair follicle epithelium generates a skin pathology that resembles LPP, and that LPP patients show gene expression changes that indicate a defect in lipid metabolism and peroxisome biogenesis. This study invites the revisitation of many open questions in PCA pathobiology and the exploration of new avenues for future PCA management.

Original languageEnglish (US)
Pages (from-to)1066-1070
Number of pages5
JournalJournal of Investigative Dermatology
Volume129
Issue number5
DOIs
StatePublished - May 2009
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Dermatology
  • Cell Biology

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