Abstract
The pathobiology of primary cicatricial ("scarring") alopecia (PCA) remains poorly understood and underinvestigated. In this issue, Karnik et al. identify a previously unsuspected player, peroxisome proliferator-activated receptor-γ (PPARγ), in the pathogenesis of the most frequent form of PCA, lichen planopilaris (LPP). The authors show that PPARγ is required for maintenance of a functional epithelial stem cell compartment in murine hair follicles, that the targeted deletion of PPARγ in the bulge/isthmus area of the hair follicle epithelium generates a skin pathology that resembles LPP, and that LPP patients show gene expression changes that indicate a defect in lipid metabolism and peroxisome biogenesis. This study invites the revisitation of many open questions in PCA pathobiology and the exploration of new avenues for future PCA management.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1066-1070 |
| Number of pages | 5 |
| Journal | Journal of Investigative Dermatology |
| Volume | 129 |
| Issue number | 5 |
| DOIs |
|
| State | Published - Jan 1 2009 |
| Externally published | Yes |
Fingerprint
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Dermatology
- Cell Biology
Cite this
Scarring alopecia and the PPAR-γ connection. / Harries, Matthew J.; Paus, Ralf.
In: Journal of Investigative Dermatology, Vol. 129, No. 5, 01.01.2009, p. 1066-1070.Research output: Contribution to journal › Comment/debate
}
TY - JOUR
T1 - Scarring alopecia and the PPAR-γ connection
AU - Harries, Matthew J.
AU - Paus, Ralf
PY - 2009/1/1
Y1 - 2009/1/1
N2 - The pathobiology of primary cicatricial ("scarring") alopecia (PCA) remains poorly understood and underinvestigated. In this issue, Karnik et al. identify a previously unsuspected player, peroxisome proliferator-activated receptor-γ (PPARγ), in the pathogenesis of the most frequent form of PCA, lichen planopilaris (LPP). The authors show that PPARγ is required for maintenance of a functional epithelial stem cell compartment in murine hair follicles, that the targeted deletion of PPARγ in the bulge/isthmus area of the hair follicle epithelium generates a skin pathology that resembles LPP, and that LPP patients show gene expression changes that indicate a defect in lipid metabolism and peroxisome biogenesis. This study invites the revisitation of many open questions in PCA pathobiology and the exploration of new avenues for future PCA management.
AB - The pathobiology of primary cicatricial ("scarring") alopecia (PCA) remains poorly understood and underinvestigated. In this issue, Karnik et al. identify a previously unsuspected player, peroxisome proliferator-activated receptor-γ (PPARγ), in the pathogenesis of the most frequent form of PCA, lichen planopilaris (LPP). The authors show that PPARγ is required for maintenance of a functional epithelial stem cell compartment in murine hair follicles, that the targeted deletion of PPARγ in the bulge/isthmus area of the hair follicle epithelium generates a skin pathology that resembles LPP, and that LPP patients show gene expression changes that indicate a defect in lipid metabolism and peroxisome biogenesis. This study invites the revisitation of many open questions in PCA pathobiology and the exploration of new avenues for future PCA management.
UR - http://www.scopus.com/inward/record.url?scp=65249089691&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=65249089691&partnerID=8YFLogxK
U2 - 10.1038/jid.2008.425
DO - 10.1038/jid.2008.425
M3 - Comment/debate
C2 - 19369934
AN - SCOPUS:65249089691
VL - 129
SP - 1066
EP - 1070
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
SN - 0022-202X
IS - 5
ER -