Scale-free behavior in protein domain networks

Research output: Contribution to journalArticlepeer-review

209 Scopus citations


Several technical, social, and biological networks were recently found to demonstrate scale-free and small-world behavior instead of random graph characteristics. In this work, the topology of protein domain networks generated with data from the ProDom, Pfam, and Prosite domain databases was studied. It was found that these networks exhibited small-world and scale-free topologies with a high degree of local clustering accompanied by a few longdistance connections. Moreover, these observations apply not only to the complete databases, but also to the domain distributions in proteomes of different organisms. The extent of connectivity among domains reflects the evolutionary complexity of the organisms considered.

Original languageEnglish (US)
Pages (from-to)1694-1702
Number of pages9
JournalMolecular biology and evolution
Issue number9
StatePublished - 2001
Externally publishedYes


  • Evolution of protein architectures
  • Protein domains
  • Scale-free and small-world topology

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Molecular Biology
  • Genetics


Dive into the research topics of 'Scale-free behavior in protein domain networks'. Together they form a unique fingerprint.

Cite this